CAJ | 학술논문

目的：探讨肝硬化患者凝血四项、D-二聚体水平及抗凝血酶Ⅲ（AT-Ⅲ）的表达及临床意义。方法选取我院2013年1月-2013年12月我院消化科收治的肝硬化患者100例为肝硬化组，按病情程度分为肝硬化代偿组54例，肝硬化失代偿组46例；另选取50例肝功能正常者为正常组。对三组对象的凝血四项包括凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）和纤维蛋白原（FIB）、D-二聚体水平及 AT-Ⅲ的含量进行检测，并进行对比分析。结果与正常组相比，肝硬化组的 PT、APTT 和 TT 显著延长（P ＜0．05），FIB 显著降低（P ＜0．05），D-二聚体含量水平显著升高（P ＜0．05），AT-Ⅲ％活性显著下降（P ＜0．05）。与代偿组相比，失代偿组的 PT、APTT 和 TT显著延长（P ＜0．05），FIB 显著降低（P ＜0．05），D-二聚体含量水平显著升高（P ＜0．05），AT-Ⅲ％活性显著下降（P ＜0．05）。结论检测凝血四项、D-二聚体水平和 AT-Ⅲ指标水平对肝硬化患者的凝血状况和病情观察具有重要的临床意义。
목적：탐토간경화환자응혈사항、D-이취체수평급항응혈매Ⅲ（AT-Ⅲ）적표체급림상의의。방법선취아원2013년1월-2013년12월아원소화과수치적간경화환자100례위간경화조，안병정정도분위간경화대상조54례，간경화실대상조46례；령선취50례간공능정상자위정상조。대삼조대상적응혈사항포괄응혈매원시간（PT）、활화부분응혈활매시간（APTT）、응혈매시간（TT）화섬유단백원（FIB）、D-이취체수평급 AT-Ⅲ적함량진행검측，병진행대비분석。결과여정상조상비，간경화조적 PT、APTT 화 TT 현저연장（P ＜0．05），FIB 현저강저（P ＜0．05），D-이취체함량수평현저승고（P ＜0．05），AT-Ⅲ％활성현저하강（P ＜0．05）。여대상조상비，실대상조적 PT、APTT 화 TT현저연장（P ＜0．05），FIB 현저강저（P ＜0．05），D-이취체함량수평현저승고（P ＜0．05），AT-Ⅲ％활성현저하강（P ＜0．05）。결론검측응혈사항、D-이취체수평화 AT-Ⅲ지표수평대간경화환자적응혈상황화병정관찰구유중요적림상의의。
Objective To explore the expression changes of coagulation four indices,D-dimer and Antithrombin Ⅲin patients with cirrhosis and its clinical significance.Methods Selected 100 cases patients with cirrhosis from digestive department during January 2013 to December 2013 as cirrhosis group.And divide the cirrhosis group into compensatory group and decompensated cirrhosis group according to the degree of disease.At the same time,50 cases of normal liver function as normal group.Tested and comparative analysis this three groups’coagulation function including the plasma prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT),fibrinogen (FIB),D-di-mer level,and the AT-Ⅲ activity.Results Compared with normal group,the PT,APTT and TT of the cirrhosis group prolong significantly.The FIB of the cirrhosis group decreased significantly.The D-dimer level of the cirrhosis group increased significantly.The AT-Ⅲ activity of the decompensated group decreased significantly.Compared with compen-satory group,the PT,APTT and TT of the decompensated group prolong significantly.The FIB of the decompensated group decreased significantly.The D-dimer level of the decompensated group increased significantly.The AT-Ⅲ activi-ty of the cirrhosis group decreased significantly.Conclusion There have important clinical significance to detection co-agulation four indices,D-dimer and Antithrombin Ⅲ in patients with cirrhosis so as to observe the patient's blood coagu-lation state and disease condition.