CAJ | 학술논문

经过多年的临床应用，盐酸普拉克索改善帕金森病运动、抑郁症状和预防运动并发症的疗效及其安全性已获得广泛认可。普拉克索缓释片与普拉克索速释片具有相同活性成分；普拉克索缓释片临床疗效和安全性与普拉克索速释片相当，且长期有效。缓释技术可保证每天1次给药，血药浓度平稳，24 h提供平稳持续的多巴胺能刺激，且不易漏服，极大地提高了依从性。超过80%的患者可由普拉克索速释片隔夜成功转换为普拉克索缓释片，且绝大多数无需剂量调整。普拉克索缓释片的上市，为帕金森病患者提供了优化治疗的新选择。文中对普拉克索缓释片的临床应用做一综述。
경과다년적림상응용，염산보랍극색개선파금삼병운동、억욱증상화예방운동병발증적료효급기안전성이획득엄범인가。보랍극색완석편여보랍극색속석편구유상동활성성분；보랍극색완석편림상료효화안전성여보랍극색속석편상당，차장기유효。완석기술가보증매천1차급약，혈약농도평은，24 h제공평은지속적다파알능자격，차불역루복，겁대지제고료의종성。초과80%적환자가유보랍극색속석편격야성공전환위보랍극색완석편，차절대다수무수제량조정。보랍극색완석편적상시，위파금삼병환자제공료우화치료적신선택。문중대보랍극색완석편적림상응용주일종술。
After years of clinical practice, the efficacy and safety of pramipexole dihydrochloride on controlling motor symptoms, improving Parkinson’s disease (PD) depression, and preventing motor complications has been widely recognized. Compared with pramipexole IR (immediate release), pramipexole SR (sustained-release) has the same active ingredient with comparable clinical efifcacy and safety, providing long-term benefit. The sustained-release form ensure daily administration with steady plasma concentrations, providing continuous dopaminergic stimulation for 24 hours. Moreover, once daily administration leads to more convenience, resulting in better compliance. More than 80%patients could be successfully switched over night from pramipexole IR to pramipexole SR, without dosage adjustment for most patients. The launch of pramipexole SR provides a new optimized treatment option for PD patients. The clinical application of pramipexole SR was reviewed.