CAJ | 학술논문

目的：：研究中药制剂丹参酮( TA）和抗肿瘤药物的卡铂( CA）联合应用对黑色素细胞瘤的抑制作用。方法：建立肿瘤模型后，分为模型组、丹参酮组、卡铂组、丹参酮＋卡铂组，同时设立正常鼠为空白组。不同组别的小鼠分别给予腹腔注射PBS、丹参酮、卡铂、丹参酮和卡铂，空白组小鼠不做任何处理。结果：丹参酮＋卡铂组小鼠的肿瘤体积和肿瘤质量显著小于丹参酮组、卡铂组和模型组( P＜0.05）；卡铂组小鼠的肿瘤体积和肿瘤质量显著小于丹参组和模型组( P＜0.05）；丹参酮＋卡铂组小鼠体重增加显著好于丹参酮组和卡铂组( P＜0.05）。结论：丹参酮和卡铂联合用药可以产生更好地抑制B16黑色素瘤增殖的效果。
목적：：연구중약제제단삼동( TA）화항종류약물적잡박( CA）연합응용대흑색소세포류적억제작용。방법：건립종류모형후，분위모형조、단삼동조、잡박조、단삼동＋잡박조，동시설립정상서위공백조。불동조별적소서분별급여복강주사PBS、단삼동、잡박、단삼동화잡박，공백조소서불주임하처리。결과：단삼동＋잡박조소서적종류체적화종류질량현저소우단삼동조、잡박조화모형조( P＜0.05）；잡박조소서적종류체적화종류질량현저소우단삼조화모형조( P＜0.05）；단삼동＋잡박조소서체중증가현저호우단삼동조화잡박조( P＜0.05）。결론：단삼동화잡박연합용약가이산생경호지억제B16흑색소류증식적효과。
Objective:To investigate the inhibitory effects produced by combination of carboplatin ( CA) and Tanshinone ( TA) on the growth of B16.Methods:After the mice were injected B16 subcutaneously in the right thigh, the mice were divided into four groups,PBS group,TA group,CA group,and TA+CA group.Normal mice were set up as control.Mice of PBS group were injected 0.2 ml PBS intraperitoneally;mice of CA group were injected 0.5 mg CA intraperitoneally for four consecutive days and followed by four days without administration until the mice were killed;mice of CA+TA group were injected 0.5 mg CA intraperitoneally for four consecutive days and followed by four days without administration,TA (0.5 g/kg body weight) was administered to the mice through gastric injection every day until the mice were killed.Results:The tumor weight and volume of CA+TA mice were significantly smaller than those of CA mice,TA mice and PBS mice ( P<0.05 );the tumor weight and volume of CA mice were significantly smaller than those of TA mice and PBS mice (P<0.05).The body weight grow of TA+CA mice was more significant than that of TA mice and CA mice( P<0.05).Conclusion:Combination of carboplatin (CA) and Tanshinone (TA) will produce a better inhibitory effects on the growth of B16 cells.