中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
8期
728-730
,共3页
宋诏民%刘子凤%尹承慧%彭勋%王宁%赵培丽%郎晓林%彭勇
宋詔民%劉子鳳%尹承慧%彭勛%王寧%趙培麗%郎曉林%彭勇
송조민%류자봉%윤승혜%팽훈%왕저%조배려%랑효림%팽용
乏血供肝癌%125I放射性粒子%顺铂%近距离放、化疗
乏血供肝癌%125I放射性粒子%順鉑%近距離放、化療
핍혈공간암%125I방사성입자%순박%근거리방、화료
Lack of blood supply from the liver cancer%125 iodine radioactive particles%Cisplatin%Radiation and chemotherapy combined from close range
目的 探讨125I放射性粒子植入联合顺铂瘤内注射治疗乏血供型原发性肝癌的临床效果.方法 选择60例乏血供型活检病理证实的肝癌患者,应用计算机随机分组,30例行125I放射性粒子植入治疗作为对照组,另30例行放射性粒子植入联合顺铂瘤内多点注射作为治疗组,术后行肿瘤体积、血常规、肝肾功能、肝内新病灶、种植性转移、随访生存期对比.结果 对照组总有效率低于治疗组[63％(19/30)与87％(26/30)],差异有统计学意义(x2=6.50,P＜0.05).对照组发现1例种植性转移,5例出现新病灶;治疗组无种植性转移,1例出现新病灶;两组肝肾功能和骨髓造血功能检测差异均无统计学意义(P均＞0.05);对照组2例死于肺、脑转移,1例死于上消化道出血;治疗组1例死于上消化道出血.两组上消化道出血发生率、新发病灶率、病死率比较差异均无统计学意义(P值分别为1.000、0.085、0.301).结论 125I放射性粒子植入近距离放疗联合顺铂瘤内局部化疗治疗乏血供肝癌,较单用125I放射性粒子植入更为有效.
目的 探討125I放射性粒子植入聯閤順鉑瘤內註射治療乏血供型原髮性肝癌的臨床效果.方法 選擇60例乏血供型活檢病理證實的肝癌患者,應用計算機隨機分組,30例行125I放射性粒子植入治療作為對照組,另30例行放射性粒子植入聯閤順鉑瘤內多點註射作為治療組,術後行腫瘤體積、血常規、肝腎功能、肝內新病竈、種植性轉移、隨訪生存期對比.結果 對照組總有效率低于治療組[63％(19/30)與87％(26/30)],差異有統計學意義(x2=6.50,P＜0.05).對照組髮現1例種植性轉移,5例齣現新病竈;治療組無種植性轉移,1例齣現新病竈;兩組肝腎功能和骨髓造血功能檢測差異均無統計學意義(P均＞0.05);對照組2例死于肺、腦轉移,1例死于上消化道齣血;治療組1例死于上消化道齣血.兩組上消化道齣血髮生率、新髮病竈率、病死率比較差異均無統計學意義(P值分彆為1.000、0.085、0.301).結論 125I放射性粒子植入近距離放療聯閤順鉑瘤內跼部化療治療乏血供肝癌,較單用125I放射性粒子植入更為有效.
목적 탐토125I방사성입자식입연합순박류내주사치료핍혈공형원발성간암적림상효과.방법 선택60례핍혈공형활검병리증실적간암환자,응용계산궤수궤분조,30례행125I방사성입자식입치료작위대조조,령30례행방사성입자식입연합순박류내다점주사작위치료조,술후행종류체적、혈상규、간신공능、간내신병조、충식성전이、수방생존기대비.결과 대조조총유효솔저우치료조[63％(19/30)여87％(26/30)],차이유통계학의의(x2=6.50,P＜0.05).대조조발현1례충식성전이,5례출현신병조;치료조무충식성전이,1례출현신병조;량조간신공능화골수조혈공능검측차이균무통계학의의(P균＞0.05);대조조2례사우폐、뇌전이,1례사우상소화도출혈;치료조1례사우상소화도출혈.량조상소화도출혈발생솔、신발병조솔、병사솔비교차이균무통계학의의(P치분별위1.000、0.085、0.301).결론 125I방사성입자식입근거리방료연합순박류내국부화료치료핍혈공간암,교단용125I방사성입자식입경위유효.
Objective To investigate the clinical curative effect of 125 iodine radioactive particles (125I) implantation combined injection of cisplatin tumor treatment to lack of blood supply of primary liver cancer.Methods Sixty patients with biopsy proven lack of blood supply hepatocellular carcinoma were randomly divided into control group and treated group:30 cases of lack of blood supply to the cancer line 125I radioactive seed implantation therapy as control group,and the other 30 cases the lack of blood supply of liver cancer radioactive particles planting row in combination with cisplatin in the tumor into the multi-point injection as treatment group.Postoperative tumor volume,blood routine examination,liver and kidney function indicators,the emergence of new liver lesions,planting metastasis,survival follow-up were compared.Results The total efficiency of the treatment group was 87％ (26/30),lower than the control group (63％ (19/30)),and the difference was statistically significant(x2=6.50,P＜0.05).One case of planting metastasis was observed in control group,new lesions was observed in 5 cases.Treatment group without planting metastasis,new lesions was observed in 1 case.Liver and kidney function test,the control group and treatment group had no significant difference(P＞0.05).In control group,there were 2 cases died of lung,brain metastases,1 case died of upper gastrointestinal bleeding.In the treatment group,there was 1 case died of upper gastrointestinal bleeding.There were significant differences in terms of the incidence of upper digestive tract bleeding,new lesions and mortality between two groups (P =1.000,0.085,0.301).Conclusion Compared with 125 I implantation therapy,125 I implantation brachytherapy combined cisplatin tumor local chemotherapy in treatment of lack of blood supply of liver cancer,is more effective.
