CAJ | 학술논문

目的：探讨血清肾素在原发性高血压患者中的分布。方法选择自2013年6月至2014年7月于青岛大学附属青岛市市立医院收治的130例未经药物治疗的原发性高血压患者为高血压组，其中男性100例，女性30例，平均年龄（47.32±10.26）岁。选取同期20例健康查体者作为正常对照组，其中男性16例，女性4例，平均年龄（44.85±8.18）岁。检测所有受试者血清肾素浓度。分别按照高血压分级标准、年龄、体质指数进行分组，比较肾素水平。结果高血压组肾素水平明显低于正常对照组[（82.13±42.5）mIU/ml vs.（130.26±54.7）mIU/ml]，差异有显著统计学意义（P＜0.01）。高血压2级、高血压3级较正常对照组和高血压1级降低，差异有统计学意义（P＜0.05）。根据年龄分为4组＜40岁、40~49岁、50~59岁、≥60岁，血清肾素浓度依次降低，但组间差异无统计学意义（P均＞0.05）。根据体质指数分为3组：＜24 kg/m2、24~28 kg/m2、＞28 kg/m2，肾素检测结果组间均数比较，差异均无统计学意义（P均＞0.05）。结论原发性高血压患者血清肾素较正常体检者降低，肾素可能参与了高血压发病。
목적：탐토혈청신소재원발성고혈압환자중적분포。방법선택자2013년6월지2014년7월우청도대학부속청도시시립의원수치적130례미경약물치료적원발성고혈압환자위고혈압조，기중남성100례，녀성30례，평균년령（47.32±10.26）세。선취동기20례건강사체자작위정상대조조，기중남성16례，녀성4례，평균년령（44.85±8.18）세。검측소유수시자혈청신소농도。분별안조고혈압분급표준、년령、체질지수진행분조，비교신소수평。결과고혈압조신소수평명현저우정상대조조[（82.13±42.5）mIU/ml vs.（130.26±54.7）mIU/ml]，차이유현저통계학의의（P＜0.01）。고혈압2급、고혈압3급교정상대조조화고혈압1급강저，차이유통계학의의（P＜0.05）。근거년령분위4조＜40세、40~49세、50~59세、≥60세，혈청신소농도의차강저，단조간차이무통계학의의（P균＞0.05）。근거체질지수분위3조：＜24 kg/m2、24~28 kg/m2、＞28 kg/m2，신소검측결과조간균수비교，차이균무통계학의의（P균＞0.05）。결론원발성고혈압환자혈청신소교정상체검자강저，신소가능삼여료고혈압발병。
Objective To discuss the distribution of serum level of renin in patients with primary hypertension. Methods The patients with primary hypertension without drug treatment (n=130, male 100, female 30 and average age=47.32±10.26) were chosen as hypertension group, and other healthy controls (n=20 male 16, female 4 and average age=44.85±8.18) were chosen as control group from Jun. 2013 to Jul. 2014. The serum level of renin was detected in all subjects. All subjects were divided into groups according to hypertension grading criterion, ages and body mass index (BMI), and renin level was compared. Results The serum level of renin was significantly lower in hypertension group than that in control group [(82.13±42.) mIU/mL vs. (130.26±54.7) mIU/mL, P<0.01], and decreased in groups of hypertension grade 2 and hypertension grade 3 compared with control group and group of hypertension grade 1 (P<0.05). The patients were divided, according to age, into age<40 group, age=40~49 group, age=50~59 group and age≥60 group, and the serum level of renin decreased in a descending order, but the difference had no statistical significance among groups (all P>0.05). The patients were divided, according to BMI, into BMI<24 kg/m2 group, BMI=24-28 kg/m2 group and BMI>28 kg/m2, and the comparison showed that mean difference had no statistical significance among groups (all P>0.05). Conclusion The serum level of renin decreases in patients with primary hypertension compared with healthy controls, while renin may participate the onset mechanism of hypertension.