浙江临床医学
浙江臨床醫學
절강림상의학
ZHEJIANG CLINICAL MEDICAL JOURNAL
2015年
8期
1306-1308
,共3页
血液灌流%血液透析%急性药物中毒
血液灌流%血液透析%急性藥物中毒
혈액관류%혈액투석%급성약물중독
Hemoperfusion%Hemodialysis%Acute poisoning of drugs
目的：探究血液灌流与血液透析合用治疗急性药物中毒的效果。方法2008年1月至2013年12月急性药物中毒患者124例临床资料。观察组在常规治疗的基础上，采用血液灌流联合血液透析治疗的模式，对照组仅使用常规治疗。以治疗效果和治疗前后的血气分析、肝肾功能、凝血功能以及APACHE-Ⅲ评分情况，来分析临床治疗的实效性，并进行统计学分析。结果观察组患者的治愈率为98.4%，住院时间为（6.14±1.63）d，昏迷时间为（7.32±2.01）h，肿瘤坏死因子-α（TNF-α）及白介素-6（IL-6）含量分别为（0.67±0.19）ng/ml和（0.22±0.20）ng/ml，均优于对照组（P<0.05）；观察组治疗后的血气指标、肝肾功能、凝血功能以及APACHE-Ⅲ评分情况等均优于治疗前，差异有统计学意义（P<0.05）。结论血液灌流与血液透析合用对于急性药物中毒患者的抢救有着重要作用，是值得深入研究的临床方法。
目的：探究血液灌流與血液透析閤用治療急性藥物中毒的效果。方法2008年1月至2013年12月急性藥物中毒患者124例臨床資料。觀察組在常規治療的基礎上，採用血液灌流聯閤血液透析治療的模式，對照組僅使用常規治療。以治療效果和治療前後的血氣分析、肝腎功能、凝血功能以及APACHE-Ⅲ評分情況，來分析臨床治療的實效性，併進行統計學分析。結果觀察組患者的治愈率為98.4%，住院時間為（6.14±1.63）d，昏迷時間為（7.32±2.01）h，腫瘤壞死因子-α（TNF-α）及白介素-6（IL-6）含量分彆為（0.67±0.19）ng/ml和（0.22±0.20）ng/ml，均優于對照組（P<0.05）；觀察組治療後的血氣指標、肝腎功能、凝血功能以及APACHE-Ⅲ評分情況等均優于治療前，差異有統計學意義（P<0.05）。結論血液灌流與血液透析閤用對于急性藥物中毒患者的搶救有著重要作用，是值得深入研究的臨床方法。
목적：탐구혈액관류여혈액투석합용치료급성약물중독적효과。방법2008년1월지2013년12월급성약물중독환자124례림상자료。관찰조재상규치료적기출상，채용혈액관류연합혈액투석치료적모식，대조조부사용상규치료。이치료효과화치료전후적혈기분석、간신공능、응혈공능이급APACHE-Ⅲ평분정황，래분석림상치료적실효성，병진행통계학분석。결과관찰조환자적치유솔위98.4%，주원시간위（6.14±1.63）d，혼미시간위（7.32±2.01）h，종류배사인자-α（TNF-α）급백개소-6（IL-6）함량분별위（0.67±0.19）ng/ml화（0.22±0.20）ng/ml，균우우대조조（P<0.05）；관찰조치료후적혈기지표、간신공능、응혈공능이급APACHE-Ⅲ평분정황등균우우치료전，차이유통계학의의（P<0.05）。결론혈액관류여혈액투석합용대우급성약물중독환자적창구유착중요작용，시치득심입연구적림상방법。
ObjectiveTo discuss the treatment effect of hemoperfusion combined hemodialysis therapy on patients with acute poisoning of drugs.Methods124 acute poisoning of drugs were randomly divided into two groups with 62 cases in each group from Jan. 2008 to Dec. 2013. Observation group were administered hemoperfusion combined hemodialysis therapy and control group were given conventional treatment. Treatment effect,and blood gas analysis,liver and kidney function,blood coagulation function in before and after treatment as indexes were evaluated as the clinical effectiveness of the two methods,and statistical analysis was done.ResultsIn observation group,the cure rate was 98.4%,hospital stays was(6.14±1.63)d,coma time was(7.32±2.01)h,concentration of TNF-α and IL-6 were(0.67±0.19)ng/ml and(0.22±0.20)ng/ml respectively. Compared with observation group,there were good uniform for control group(P<0.05). Compared with observation group after treatment,there were better than before treatment in overall indexes,which was much more accurate(P<0.05).ConclusionHemoperfusion combined hemodialysis therapy is an important role for patients with acute poisoning of drugs. This clinical treatment method is worthy of further study.
