CAJ | 학술논문

目的：探讨长链非编码RNA（LncRNA）CRNDE在宫颈癌中表达及其临床意义。方法：收集广东省开平市中心医院行手术切除的宫颈癌组织及癌旁组织标本87例，实时荧光定量PCR（RT-PCR）检测LncRNA CRNDE表达差异，分析其与临床病理特征的关系。结果：与癌旁组织比较LncRNA CRNDE在宫颈癌组织中呈高表达（P<0.05）。LncRNA CRNDE高表达与宫颈癌FIGO分期，淋巴结转移，肿瘤的侵袭深度相关。此外，LncRNA CRNDE高表达较低表达者的生存时间缩短（P<0.05）。Cox回归多因素分析发现LncRNA CRNDE可作为宫颈癌患者独立的预后因子。结论：LncRNA CRNDE可作为宫颈癌独立的预后标志物和潜在的治疗靶点。
목적：탐토장련비편마RNA（LncRNA）CRNDE재궁경암중표체급기림상의의。방법：수집광동성개평시중심의원행수술절제적궁경암조직급암방조직표본87례，실시형광정량PCR（RT-PCR）검측LncRNA CRNDE표체차이，분석기여림상병리특정적관계。결과：여암방조직비교LncRNA CRNDE재궁경암조직중정고표체（P<0.05）。LncRNA CRNDE고표체여궁경암FIGO분기，림파결전이，종류적침습심도상관。차외，LncRNA CRNDE고표체교저표체자적생존시간축단（P<0.05）。Cox회귀다인소분석발현LncRNA CRNDE가작위궁경암환자독립적예후인자。결론：LncRNA CRNDE가작위궁경암독립적예후표지물화잠재적치료파점。
Objective:To investigate the expression and clinical significance of long non-coding RNA (LncRNA) CRNDE in cer-vical cancer. Methods:Specimens of cervical cancer tissues and matched non-tumor para-neoplastic tissues were collected from 87 pa-tients who underwent surgery in the Kaiping Central Hospital, China. Quantitative real-time PCR was used to examine the expression of LncRNA CRNDE, and its correlation with clinicopathological features was analyzed. Results:LncRNA CRNDE expression was sig-nificantly up-regulated in cervical cancer tissues than in adjacent non-tumor tissues (P<0.05). Increased LncRNA CRNDE expression was significantly correlated with FIGO stage, lymph node metastasis, and depth of cervical invasion (P<0.05). Moreover, a higher ex-pression of LncRNA CRNDE demonstrated significantly poorer overall survival in cervical cancer patients than in those with lower Ln-cRNA CRNDE expression (P<0.05). Multivariate analyses suggested that LncRNA CRNDE expression served as an independent pre-dictor for overall survival. Conclusion:Our findings posit that LncRNA CRNDE may be a potential prognostic marker and therapeutic target for cervical cancer.