CAJ | 학술논문

YAP是一种多功能蛋白，可以与不同的转录因子相互作用激活基因的表达。YAP作为活化Hippo途径的关键转录调节蛋白在调节器官大小、细胞自我更新、干细胞和组织特异性祖细胞扩增等方面发挥重要作用，在Hippo途径中MST1/2激酶和其结合蛋白SAV共同磷酸化激酶LATS1/2，激活的LATS1/2磷酸化YAP从而抑制YAP蛋白的活性。近年来，大量的研究已经在胚胎干细胞、神经干细胞、造血干细胞中发现YAP的高表达能够维持干细胞干性并且已经成为维持干性的标志物，随后的研究发现信号通路可能与肿瘤干细胞（CSC）分化密切相关。本文主要讨论YAP在维持干细胞及肿瘤干细胞干性方面的作用。
YAP시일충다공능단백，가이여불동적전록인자상호작용격활기인적표체。YAP작위활화Hippo도경적관건전록조절단백재조절기관대소、세포자아경신、간세포화조직특이성조세포확증등방면발휘중요작용，재Hippo도경중MST1/2격매화기결합단백SAV공동린산화격매LATS1/2，격활적LATS1/2린산화YAP종이억제YAP단백적활성。근년래，대량적연구이경재배태간세포、신경간세포、조혈간세포중발현YAP적고표체능구유지간세포간성병차이경성위유지간성적표지물，수후적연구발현신호통로가능여종류간세포（CSC）분화밀절상관。본문주요토론YAP재유지간세포급종류간세포간성방면적작용。
Yes-associated protein (YAP) is a multifunctional protein that can interact with different transcription factors to acti-vate gene expression. YAP, as the key transcription protein of Hippo pathway, has made important contribution to the control of the or-gan size, stem cell biology, and tissue-specific stem cell self-renewal. In the Hippo pathway, MST1/2 kinases, together with the adaptor protein SAV, phosphorylate LATS1/2 kinases. YAP is phosphorylated and inhibited by the activated LATS1/2, a key component of the Hippo tumor suppressor pathway. In recent years, numerous studies have shown that the high expression of YAP in the embryonic stem cells, neural stem cells, and hematopoietic stem cells can maintain the cancer stem cell;and YAP has become the marker of cancer stem cells. Meanwhile, more and more studies indicate that the disorder of Hippo-YAP signaling pathway may be associated with cancer stem cells. In this review, we mainly discuss the role of the Hippo pathway in the stem cell biology and its potential implications in tis-sue homeostasis and cancer.