世界最新医学信息文摘（连续型电子期刊）
世界最新醫學信息文摘（連續型電子期刊）
세계최신의학신식문적（련속형전자기간）
World Latest Medicine Information
2015年
42期
26-27
,共2页
恶性腹水%癌胚抗原信使核糖核酸%糖类抗原19-9%腹腔灌注化疗%疗效
噁性腹水%癌胚抗原信使覈糖覈痠%糖類抗原19-9%腹腔灌註化療%療效
악성복수%암배항원신사핵당핵산%당류항원19-9%복강관주화료%료효
Malignant ascites%CEAmRNA%CA19-9%Intraperitoneal perfusion chemotherapy%Effect
目的：观察恶性腹水中腹腔化疗前后癌胚抗原信使核糖核酸(Carcinoembryonic antigen message RNA,CEAmRNA)和糖链抗原19-9(CA19-9)的变化及其意义。方法恶性腹水标本化疗前后各56份，采用逆转录套式聚合酶链反应(RT-NP-PCR)检测CEAmRNA，电化学发光法检测CA19-9。结果 CEAmRNA检出率由化疗前98.2%(55/56)降至化疗后85.7%(48/56)，P<0.05(x2=5.920)；CA19-9由化疗前(69.4±11.5)μ/mL降至化疗后(52.1±9.3)μ/mL，P<0.01(t=8.550)。结论恶性腹水标本可以检测到较高水平的CEAmRNA和CA19-9阳性结果，提示二者在恶性腹水时被高度活性表达，当腹腔灌注化疗后，二者也显著降低，其测定值可作为疗效评价判别的参考。
目的：觀察噁性腹水中腹腔化療前後癌胚抗原信使覈糖覈痠(Carcinoembryonic antigen message RNA,CEAmRNA)和糖鏈抗原19-9(CA19-9)的變化及其意義。方法噁性腹水標本化療前後各56份，採用逆轉錄套式聚閤酶鏈反應(RT-NP-PCR)檢測CEAmRNA，電化學髮光法檢測CA19-9。結果 CEAmRNA檢齣率由化療前98.2%(55/56)降至化療後85.7%(48/56)，P<0.05(x2=5.920)；CA19-9由化療前(69.4±11.5)μ/mL降至化療後(52.1±9.3)μ/mL，P<0.01(t=8.550)。結論噁性腹水標本可以檢測到較高水平的CEAmRNA和CA19-9暘性結果，提示二者在噁性腹水時被高度活性錶達，噹腹腔灌註化療後，二者也顯著降低，其測定值可作為療效評價判彆的參攷。
목적：관찰악성복수중복강화료전후암배항원신사핵당핵산(Carcinoembryonic antigen message RNA,CEAmRNA)화당련항원19-9(CA19-9)적변화급기의의。방법악성복수표본화료전후각56빈，채용역전록투식취합매련반응(RT-NP-PCR)검측CEAmRNA，전화학발광법검측CA19-9。결과 CEAmRNA검출솔유화료전98.2%(55/56)강지화료후85.7%(48/56)，P<0.05(x2=5.920)；CA19-9유화료전(69.4±11.5)μ/mL강지화료후(52.1±9.3)μ/mL，P<0.01(t=8.550)。결론악성복수표본가이검측도교고수평적CEAmRNA화CA19-9양성결과，제시이자재악성복수시피고도활성표체，당복강관주화료후，이자야현저강저，기측정치가작위료효평개판별적삼고。
Objective:To observe the effects of malignant ascites intraperitoneal chemotherapy carcinoembryonic antigen messenger ribonucleic acid (carcinoembryonic antigen message RNA, CEAmRNA) and carbohydrate antigen 19-9 (CA19-9) changes and its significance.Methods: 56 patients with malignant ascites were detected by reverse transcription nested polymerase chain reaction (RT-NP-PCR) and CEAmRNA, respectively, and CA19-9 was detected by using reverse transcription nested polymerase chain reaction Results: CEAmRNA detection rate by chemotherapy before 98.2% (55 / 56) fell to chemotherapy after 85.7% (48 / 56),P< 0.05 (x2=5.920); CA19-9 by before chemotherapy (69.4 + 11.5) U / ml decreased after chemotherapy (52.1 + 9.3) U / ml,P < 0.01 (t=8.550. Conclusion:Malignant ascites specimens can be detected higher levels of CEA and CA19-9 positive results, suggesting that both in malignant ascites was highly active expression, when intraperitoneal chemotherapy, both significantly decreased, the determination as a discriminant in efficacy evaluation of reference value.
