医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2015年
3期
19-21
,共3页
妊娠期高血压疾病%胰岛素抵抗%凝血功能
妊娠期高血壓疾病%胰島素牴抗%凝血功能
임신기고혈압질병%이도소저항%응혈공능
Pregnancy hypertension disease%Insulin resistance%Blood coagulation function
目的：探究妊娠高血压病患胰岛素抵抗和凝血功能异常之间的关联性。方法：选取2011年12月~2013年12月我院住院部109例孕妇为研究对象，平均年龄为（25.5±5.6）岁。所有孕妇均为初产妇。且无其他器官器质性病变。109例孕妇分成治疗组（妊娠高血压病患），和对照组（正常孕妇），其中对照组55例，治疗组54例。利用电化学分析模块，对病患OGTT测试，同时检测病患胰岛素水平。利用HOMA指数当作病患胰岛素的抵抗指标，取病患静脉血液0.2毫升（109毫摩尔每升）加入枸橼酸钠进行配比抗凝。检测病患血浆中的PT,APTT，Fbg指标。结果：与正常组相比，治疗组的HOMA, Fbg,均有显著性降低，组间差异P＜0.05，认为有统计学意义。PT与APTT值则显著性升高，组间差异P＜0.05，认为有统计学意义。治疗组与对照组的Fbg和HOMA水平变化呈负相关性，APTT和PT水平变化呈正相关性。结论：妊娠高血压病患的一袋苏抵抗指数和其自身凝血功能存在密切关联。在根本上提示了该指数是引发妊娠高血压的重要原因，且两者之间存在着互相影响的关系，对妊娠高血压症的疾病产生和发展起到了协同作用。
目的：探究妊娠高血壓病患胰島素牴抗和凝血功能異常之間的關聯性。方法：選取2011年12月~2013年12月我院住院部109例孕婦為研究對象，平均年齡為（25.5±5.6）歲。所有孕婦均為初產婦。且無其他器官器質性病變。109例孕婦分成治療組（妊娠高血壓病患），和對照組（正常孕婦），其中對照組55例，治療組54例。利用電化學分析模塊，對病患OGTT測試，同時檢測病患胰島素水平。利用HOMA指數噹作病患胰島素的牴抗指標，取病患靜脈血液0.2毫升（109毫摩爾每升）加入枸櫞痠鈉進行配比抗凝。檢測病患血漿中的PT,APTT，Fbg指標。結果：與正常組相比，治療組的HOMA, Fbg,均有顯著性降低，組間差異P＜0.05，認為有統計學意義。PT與APTT值則顯著性升高，組間差異P＜0.05，認為有統計學意義。治療組與對照組的Fbg和HOMA水平變化呈負相關性，APTT和PT水平變化呈正相關性。結論：妊娠高血壓病患的一袋囌牴抗指數和其自身凝血功能存在密切關聯。在根本上提示瞭該指數是引髮妊娠高血壓的重要原因，且兩者之間存在著互相影響的關繫，對妊娠高血壓癥的疾病產生和髮展起到瞭協同作用。
목적：탐구임신고혈압병환이도소저항화응혈공능이상지간적관련성。방법：선취2011년12월~2013년12월아원주원부109례잉부위연구대상，평균년령위（25.5±5.6）세。소유잉부균위초산부。차무기타기관기질성병변。109례잉부분성치료조（임신고혈압병환），화대조조（정상잉부），기중대조조55례，치료조54례。이용전화학분석모괴，대병환OGTT측시，동시검측병환이도소수평。이용HOMA지수당작병환이도소적저항지표，취병환정맥혈액0.2호승（109호마이매승）가입구연산납진행배비항응。검측병환혈장중적PT,APTT，Fbg지표。결과：여정상조상비，치료조적HOMA, Fbg,균유현저성강저，조간차이P＜0.05，인위유통계학의의。PT여APTT치칙현저성승고，조간차이P＜0.05，인위유통계학의의。치료조여대조조적Fbg화HOMA수평변화정부상관성，APTT화PT수평변화정정상관성。결론：임신고혈압병환적일대소저항지수화기자신응혈공능존재밀절관련。재근본상제시료해지수시인발임신고혈압적중요원인，차량자지간존재착호상영향적관계，대임신고혈압증적질병산생화발전기도료협동작용。
Objective: To explore the relationship between pregnancy induced hypertension patients with insulin resistance and coagulation abnormalities.Methods:Selection in December 2011 to December 2013 in our hospital wards, 109 cases of pregnant women as the research object, the average age was (25.5 + / - 5.6). All pregnant women are mothers. And no other organs implement qualitative sex pathological change. 109 cases of pregnant women were divided into treatment group (pregnancy-induced hypertension patients), and the control group (normal pregnant women), including control group 55 cases, treatment group of 54 cases. OGTT test using electrochemical analysis module, the patient, at the same time to detect patients with insulin levels. Using the index of HOMA insulin resistance index as a patient, in patients with venous blood 0.2 ml (109 millimoles per liter) join ratio of sodium citrate for anticoagulation. Testing in patients plasma PT, APTT and Fbg indicators.Results: Compared with the normal group, hypertension group HOMA, Fbg, were significantly lower, the difference between groupP<0.05, believe that there is a statistically significant. PT and APTT values are significantly increased, the difference between groupP<0.05, believe that there is a statistically significant. Treatment group and control group of Fbg and HOMA level changes showed a negative correlation, positive correlation between APTT and PT level change.Conclusions:A bag of gestational hypertension patients Sue resistance index and its coagulation function closely related. In the root tip of the index is one of the important reasons caused by pregnancy-induced hypertension, and the mutual influences between the two, emergence and development of gestational hypertension disease has played a synergy.
