中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
7期
185-188
,共4页
骨性关节炎%发病机制%关节腔注射%微球%研究进展
骨性關節炎%髮病機製%關節腔註射%微毬%研究進展
골성관절염%발병궤제%관절강주사%미구%연구진전
osteoarthritis%pathogenesis%articular injection%microspheres%progress
目的：总结了骨关节炎的发病机制和微球给药系统在骨关节炎治疗领域的研究进展，为临床上骨关节炎的研究和治疗提供理论支持。方法参考近年来国内外关于骨性关节炎的文献，对骨关节炎的发病机制和治疗方法进行综述。结果目前骨性关节炎的治疗，逐渐从缓解症状向发病机制方面深入研究，进一步揭示了骨性关节炎治疗的内在规律性。然而，中西医疗法都有各自的局限性。结论近年来关节腔注射给药治疗骨性关节炎显示出独特的优势，尤其以微球为载体的注射剂，在新剂型领域研究的较多，具有优越的发展前景。
目的：總結瞭骨關節炎的髮病機製和微毬給藥繫統在骨關節炎治療領域的研究進展，為臨床上骨關節炎的研究和治療提供理論支持。方法參攷近年來國內外關于骨性關節炎的文獻，對骨關節炎的髮病機製和治療方法進行綜述。結果目前骨性關節炎的治療，逐漸從緩解癥狀嚮髮病機製方麵深入研究，進一步揭示瞭骨性關節炎治療的內在規律性。然而，中西醫療法都有各自的跼限性。結論近年來關節腔註射給藥治療骨性關節炎顯示齣獨特的優勢，尤其以微毬為載體的註射劑，在新劑型領域研究的較多，具有優越的髮展前景。
목적：총결료골관절염적발병궤제화미구급약계통재골관절염치료영역적연구진전，위림상상골관절염적연구화치료제공이론지지。방법삼고근년래국내외관우골성관절염적문헌，대골관절염적발병궤제화치료방법진행종술。결과목전골성관절염적치료，축점종완해증상향발병궤제방면심입연구，진일보게시료골성관절염치료적내재규률성。연이，중서의요법도유각자적국한성。결론근년래관절강주사급약치료골성관절염현시출독특적우세，우기이미구위재체적주사제，재신제형영역연구적교다，구유우월적발전전경。
Objective To review the pathogenesis of osteoarthritis ( OA) and microsphere delivery systems advances in the field of osteoarthritis treatment, and provide theoretical support for clinical research and osteoarthritis therapy.Methods The literatures on osteoarthritis have been reviewed in recent years, and pathogenesis and osteoarthritis therapy were summarized.ResuIts At present, the therapy of OA was gradually from symptoms relief to pathogenesis, and further revealed the inner regularity of osteoarthritis treatment.However, a variety of western medicines had its own limitations. ConcIusion In recent years, intra-articular injection therapy because of its unique advantages in clinical treatments,attracts widespread attention, and particularly the microsphere injection with superior prospects is researched more in the field of new formulations.
