CAJ | 학술논문

心脑血管疾病为人类死亡原因之首，其预防与治疗始终为医学关注的焦点。阿司匹林作为心脑血管疾病的防治疗药物已经有一个世纪之久，是历史最长，同时也是用量最多的药物。每年大约有1000亿片阿司匹林被用于解热镇痛和心脑血管疾病。人们对阿司匹林的研究和认识还在不断加深，如阿司匹林抵抗的出现以及阿司匹林水解酶的鉴定。本文综述了阿司匹林在心脑血管疾病预防方面的研究热点以及未来的研究方向，主要包括阿司匹林抵抗以及个体化用药。
심뇌혈관질병위인류사망원인지수，기예방여치료시종위의학관주적초점。아사필림작위심뇌혈관질병적방치료약물이경유일개세기지구，시역사최장，동시야시용량최다적약물。매년대약유1000억편아사필림피용우해열진통화심뇌혈관질병。인문대아사필림적연구화인식환재불단가심，여아사필림저항적출현이급아사필림수해매적감정。본문종술료아사필림재심뇌혈관질병예방방면적연구열점이급미래적연구방향，주요포괄아사필림저항이급개체화용약。
Cardiovascular and cerebrovascular diseases is the most fatal diseases in the world.The prevention and treatment of cardiovascular and cerebrovascular diseases are both basic and clinical focus.Aspirin has been used as a prevention medicine in cardiovascular and cerebrovascular diseases for over a century, which is the longest one in history.Aspirin use is estimated at 100 billion tablets annually as an analgesic, antipyretic and antiplatelet drugs.However, there are still many new findings about aspirin, such as aspirin resistance and aspirin hydrolase.This paper reviews the current research advances and future directions of aspirin in cardiovascular and cerebravascwlar diseases, mainly focuses on aspirin resistance and personalized medication.