CAJ | 학술논문

目的：探讨复方血栓通胶囊对下肢静脉血栓患者血清纤溶酶原激活物抑制剂（serpine1）、α－抗胰蛋白酶1（α－serpine1）蛋白及Kruppel样转录因子2（KLF2）的影响。方法选取贵州省安顺市人民医院已确诊为下肢静脉血栓形成的患者44例，随机分为实验组和对照组，各22例，患者均给予常规抗血小板治疗，实验组在此基础上给予复方血栓通胶囊1．5 g／次，3次／天口服，对照组给予脉络舒通颗粒20 g／次，3次／天冲服。2周为1个疗程，治疗3个疗程。治疗前后检测2组患者血清serpine1、α－serpine1蛋白及KLF2含量、血液流变学、凝血功能指标。结果与对照组比较，实验组患者的疗效更好，表现为：血清serpine1、α－serpine1蛋白含量显著降低（P＜0．05）；KLF2表达量明显升高（P＜0．05）；血液粘度、红细胞聚集指数、血沉速度明显降低（P＜0．05）；FIB、D－D含量明显降低（ P＜0．05）。结论复方血栓通胶囊可以降低下肢静脉血栓患者血清serpine1、α－serpine1蛋白含量，促进KLF2表达，降低血液粘度、血沉速度，改善患者的高凝状态，取得良好的临床疗效。
목적：탐토복방혈전통효낭대하지정맥혈전환자혈청섬용매원격활물억제제（serpine1）、α－항이단백매1（α－serpine1）단백급Kruppel양전록인자2（KLF2）적영향。방법선취귀주성안순시인민의원이학진위하지정맥혈전형성적환자44례，수궤분위실험조화대조조，각22례，환자균급여상규항혈소판치료，실험조재차기출상급여복방혈전통효낭1．5 g／차，3차／천구복，대조조급여맥락서통과립20 g／차，3차／천충복。2주위1개료정，치료3개료정。치료전후검측2조환자혈청serpine1、α－serpine1단백급KLF2함량、혈액류변학、응혈공능지표。결과여대조조비교，실험조환자적료효경호，표현위：혈청serpine1、α－serpine1단백함량현저강저（P＜0．05）；KLF2표체량명현승고（P＜0．05）；혈액점도、홍세포취집지수、혈침속도명현강저（P＜0．05）；FIB、D－D함량명현강저（ P＜0．05）。결론복방혈전통효낭가이강저하지정맥혈전환자혈청serpine1、α－serpine1단백함량，촉진KLF2표체，강저혈액점도、혈침속도，개선환자적고응상태，취득량호적림상료효。
Objective To explore the effect of serpine1, α-serpine1 protein and KLF2 in patients with lower extremity venous thrombosis by Fufang Xueshuantong capsule.Methods 44 patients were diagnosed with lower extremity venous thrombosis were collected, and randomly divided into experimental group and control group, 22 cases in each group, giving the conventional antiplatelet therapy, on the basis of this, the experimental group was given Fufang Xueshuantong capsule 1.5 g, three times a day orally, and the control group was given context Shutong granules 20 g, three times a day orally.2 weeks for a course of treatment, three courses of treatment.Before and after treatment in the detection of two groups of patients with serum serpine1, α-serpine1 KLF2 and protein contents, blood rheology, coagulation function, and carries on the analysis.ResuIts Compared with the control group, experimental group patients has better curative effect, the performance of: serum serpine1and α-serpine1 protein content were significantly decreased(P<0.05).KLF2 expression was significantly higher (P<0.05).Blood viscosity, erythrocyte aggregation index, erythrocyte sedimentation rate decreased significantly (P<0.05).Fib, D-D content significantly decreased (P<0.05).ConcIusions Fufang Xueshuantong capsule can reduce serum serpine1, α-serpine1 protein content and promote KLF2 expression, decrease the blood viscosity, erythrocyte sedimentation rate, improve patients with hypercoagulable state in patients with lower extremity venous thrombosis, so as to achieve good clinical efficacy.