中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
7期
133-137
,共5页
王大卫%温宝芳%商洪才%冯占芹%张维芬
王大衛%溫寶芳%商洪纔%馮佔芹%張維芬
왕대위%온보방%상홍재%풍점근%장유분
原花青素%白芨多糖%壳聚糖%喷雾干燥%微球%理化特性
原花青素%白芨多糖%殼聚糖%噴霧榦燥%微毬%理化特性
원화청소%백급다당%각취당%분무간조%미구%이화특성
proanthocyanidins%bletilla striata polysaccharide%chitosan%spray drying%microshpere%physiochemical properties
目的：制备原花青素／白芨多糖／壳聚糖微球并对其理化特性进行考察。方法采用喷雾干燥法制备原花青素／白芨多糖／壳聚糖微球，扫描电镜观察不同药物载体比例微球的粒径、外观，并对其体外释放、含水率、溶胀率、固密度等理化特性进行考察。结果喷雾干燥法成功构建原花青素／白芨多糖／壳聚糖微球A、B、C3种微球，电镜结果显示原花青素／白芨多糖／壳聚糖微球平均外观圆整，表面有褶皱，粒径在2～15μm分布均匀；体外释放结果表明，原花青素A、B、C 3种微球累计释放分别为25．07％、38．83％和60．00％，无突释现象；原花青素24 h时累计释放分别为28．42％、41．82％和67．52％，48 h累计释放分别为28．89％、43．17％和72．86％，微球具有缓释作用。含水率、溶胀率、固密度结果分为15．35％～23．51％、46．50％～105．80％、0．375～0．496。结论喷雾干燥法成功构建原花青素／白芨多糖／壳聚糖微球，微球表面有褶皱，粒径固密度、溶胀等特性良好，具有缓释作用，有望成为肺吸入给药的良好载体。
目的：製備原花青素／白芨多糖／殼聚糖微毬併對其理化特性進行攷察。方法採用噴霧榦燥法製備原花青素／白芨多糖／殼聚糖微毬，掃描電鏡觀察不同藥物載體比例微毬的粒徑、外觀，併對其體外釋放、含水率、溶脹率、固密度等理化特性進行攷察。結果噴霧榦燥法成功構建原花青素／白芨多糖／殼聚糖微毬A、B、C3種微毬，電鏡結果顯示原花青素／白芨多糖／殼聚糖微毬平均外觀圓整，錶麵有褶皺，粒徑在2～15μm分佈均勻；體外釋放結果錶明，原花青素A、B、C 3種微毬纍計釋放分彆為25．07％、38．83％和60．00％，無突釋現象；原花青素24 h時纍計釋放分彆為28．42％、41．82％和67．52％，48 h纍計釋放分彆為28．89％、43．17％和72．86％，微毬具有緩釋作用。含水率、溶脹率、固密度結果分為15．35％～23．51％、46．50％～105．80％、0．375～0．496。結論噴霧榦燥法成功構建原花青素／白芨多糖／殼聚糖微毬，微毬錶麵有褶皺，粒徑固密度、溶脹等特性良好，具有緩釋作用，有望成為肺吸入給藥的良好載體。
목적：제비원화청소／백급다당／각취당미구병대기이화특성진행고찰。방법채용분무간조법제비원화청소／백급다당／각취당미구，소묘전경관찰불동약물재체비례미구적립경、외관，병대기체외석방、함수솔、용창솔、고밀도등이화특성진행고찰。결과분무간조법성공구건원화청소／백급다당／각취당미구A、B、C3충미구，전경결과현시원화청소／백급다당／각취당미구평균외관원정，표면유습추，립경재2～15μm분포균균；체외석방결과표명，원화청소A、B、C 3충미구루계석방분별위25．07％、38．83％화60．00％，무돌석현상；원화청소24 h시루계석방분별위28．42％、41．82％화67．52％，48 h루계석방분별위28．89％、43．17％화72．86％，미구구유완석작용。함수솔、용창솔、고밀도결과분위15．35％～23．51％、46．50％～105．80％、0．375～0．496。결론분무간조법성공구건원화청소／백급다당／각취당미구，미구표면유습추，립경고밀도、용창등특성량호，구유완석작용，유망성위폐흡입급약적량호재체。
Objective To prepare proanthocyanidins/bletilla striata polysaccharide/chitosan microspheres ( PC/BSP/CTS ) and the physic-chemical characterizations were investigated.Methods The PC/BSP/CTS microspheres were prepared by spray drying method.The morphology of PC/BSP/CTS microspheres was observed by Scanning Electron Microscopy(SEM), and its physic-chemical characteristics such as diameters, release in vitro, moisture content, swelling ratio, solid density were studied.ResuIts The PC/BSP/CTS microspheres were successfully prepared by spray drying method, SEM showed that PC/BSP/CTS microspheres had the spherical shape with smooth surfaces.The diameters of microsphere A, B and C were 10~20, 2~15, 10~25μm.The in-vitro release showed that the cumulative release of three kinds of microspheres A, B, C was 25.07 %, 38.83 %and 60.00 % in 24 h, which had no burst release, while with time prolonged to 48 h, the cumulative release was 28.89%, 43.17% and 72.86%, respectively.The results of moisture content, swelling ratio, solid density were 15.35% ~23.51%, 46.50% ~105.80%, 0.375 ~0.496. ConcIusion The PC/BSP/CTS microspheres are successfully prepared by spray drying method which possess good characteristics and sustained-release effect, which would be as a good pulmonary drug delivery system.
