CAJ | 학술논문

目的：探讨自拟消肿散结汤联合左甲状腺素钠片治疗甲状腺结节的临床疗效。方法选取2013年7月～2014年7月来杭州市余杭区第一人民医院就诊的甲状腺结节患者52例，按照随机数字表法分为对照组（ n＝25）和研究组（ n＝27）。其中对照组给予左甲状腺素钠片，研究组在对照组的基础上加用自拟消肿散结汤。疗程均为24周。分别于治疗前后记录2组的促甲状腺激素（ thyroid stimulating hormone， TSH ）、游离三碘甲状腺原氨酸（ free triiodothyronine， FT3）、血清游离四碘甲状腺原氨酸（ free tetraiodothyronine，FT4）水平及甲状腺结节大小变化。结果治疗24周后，2组甲状腺结节均明显缩小，且研究组的缩小幅度大于对照组（P＜0．05）；2组TSH水平与治疗前相比均明显下降，且研究组的下降幅度大于对照组（P＜0．05）；2组FT4水平与治疗前相比均明显升高，且研究组的升高幅度大于对照组（P＜0．05）；FT3研究组治疗的总有效率为（77．78％）明显优于对照组（48．00％，P＜0．05）。结论自拟消肿散结汤联合左甲状腺素钠片治疗甲状腺结节效果显著，能有效控制或缩小甲状腺结节。
목적：탐토자의소종산결탕연합좌갑상선소납편치료갑상선결절적림상료효。방법선취2013년7월～2014년7월래항주시여항구제일인민의원취진적갑상선결절환자52례，안조수궤수자표법분위대조조（ n＝25）화연구조（ n＝27）。기중대조조급여좌갑상선소납편，연구조재대조조적기출상가용자의소종산결탕。료정균위24주。분별우치료전후기록2조적촉갑상선격소（ thyroid stimulating hormone， TSH ）、유리삼전갑상선원안산（ free triiodothyronine， FT3）、혈청유리사전갑상선원안산（ free tetraiodothyronine，FT4）수평급갑상선결절대소변화。결과치료24주후，2조갑상선결절균명현축소，차연구조적축소폭도대우대조조（P＜0．05）；2조TSH수평여치료전상비균명현하강，차연구조적하강폭도대우대조조（P＜0．05）；2조FT4수평여치료전상비균명현승고，차연구조적승고폭도대우대조조（P＜0．05）；FT3연구조치료적총유효솔위（77．78％）명현우우대조조（48．00％，P＜0．05）。결론자의소종산결탕연합좌갑상선소납편치료갑상선결절효과현저，능유효공제혹축소갑상선결절。
Objective To observe clinical effect of self-made xiaozhongsanjie decoction combined with levothyroxine sodium tablets in treatment of thyroid nodule.Methods From July 2013 to July 2014, 52 cases of thyroid nodule patients were randomly divided into two groups: control group( n=25)and study group(n=27).The control group were received levothyroxine sodium tablets, while the study group were given self-made xiaozhongsanjie decoction on the basis of control group.Both groups were treated for 24 weeks.The changes of thyroid stimulating hormone ( TSH ) , serum free triiodothyronine (FT3), serum free tetraiodothyronine (FT4) levels, and the thyroid nodule size of two groups before and after treatment were recorded and compared.ResuIts After 24 weeks’ treatment, the thyroid nodule size of both groups reduced, and the descending range of study group was much larger than that of control group (P<0.05).The TSH levels of both groups descended, and the descending range of study group was much larger than control group (P<0.05).While the FT4 levels all increased in both groups, and the ascending range of study group was much larger than control group (P<0.05).And the total effective rate of study group was 77.78%, which was significantly higher than control group (48.00%, P<0.05). ConcIusion The therapy of self-made xiaozhongsanjie decoction combined with levothyroxine sodium tablets in treatment of thyroid nodule could control or reduce the thyroid nodule size effectively.