中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
7期
125-127
,共3页
聚维酮碘冲洗%左氧氟沙星滴眼液%白内障%炎性指标%抗氧化指标
聚維酮碘遲洗%左氧氟沙星滴眼液%白內障%炎性指標%抗氧化指標
취유동전충세%좌양불사성적안액%백내장%염성지표%항양화지표
povidone iodine irrigation%levofloxacin eye drops%cataract%inflammatory indexes%antioxidant indexes
目的：探讨聚维酮碘冲洗联合左氧氟沙星滴眼液对糖尿病合并白内障患者血清及泪液中炎性指标、NO及抗氧化指标的影响。方法以2013年1月～2015年1月收治的50例糖尿病合并白内障患者为研究对象，均接受白内障手术，随机双盲法将患者分为2组，各25例，对照组术前左氧氟沙星滴眼液干预，观察组在对照组基础上联合聚维酮碘冲洗，比较2组冲洗前后炎性指标（IL－2、sIL－2R、IL－6）、NO、抗氧化指标（TAC、SOD、CAT）及术后感染情况。结果观察组冲洗后血清及泪液中sIL－2R、IL－6、NO水平明显低于对照组（P＜0．05），IL－2、TAC、SOD、CAT明显高于对照组（P＜0．05）。观察组术后感染率为0，显著低于对照组的16．0％（P＜0．05）。结论聚维酮碘冲洗联合左氧氟沙星滴眼液能明显减轻糖尿病合并白内障患者术前炎性反应，提高其抗氧化水平。
目的：探討聚維酮碘遲洗聯閤左氧氟沙星滴眼液對糖尿病閤併白內障患者血清及淚液中炎性指標、NO及抗氧化指標的影響。方法以2013年1月～2015年1月收治的50例糖尿病閤併白內障患者為研究對象，均接受白內障手術，隨機雙盲法將患者分為2組，各25例，對照組術前左氧氟沙星滴眼液榦預，觀察組在對照組基礎上聯閤聚維酮碘遲洗，比較2組遲洗前後炎性指標（IL－2、sIL－2R、IL－6）、NO、抗氧化指標（TAC、SOD、CAT）及術後感染情況。結果觀察組遲洗後血清及淚液中sIL－2R、IL－6、NO水平明顯低于對照組（P＜0．05），IL－2、TAC、SOD、CAT明顯高于對照組（P＜0．05）。觀察組術後感染率為0，顯著低于對照組的16．0％（P＜0．05）。結論聚維酮碘遲洗聯閤左氧氟沙星滴眼液能明顯減輕糖尿病閤併白內障患者術前炎性反應，提高其抗氧化水平。
목적：탐토취유동전충세연합좌양불사성적안액대당뇨병합병백내장환자혈청급루액중염성지표、NO급항양화지표적영향。방법이2013년1월～2015년1월수치적50례당뇨병합병백내장환자위연구대상，균접수백내장수술，수궤쌍맹법장환자분위2조，각25례，대조조술전좌양불사성적안액간예，관찰조재대조조기출상연합취유동전충세，비교2조충세전후염성지표（IL－2、sIL－2R、IL－6）、NO、항양화지표（TAC、SOD、CAT）급술후감염정황。결과관찰조충세후혈청급루액중sIL－2R、IL－6、NO수평명현저우대조조（P＜0．05），IL－2、TAC、SOD、CAT명현고우대조조（P＜0．05）。관찰조술후감염솔위0，현저저우대조조적16．0％（P＜0．05）。결론취유동전충세연합좌양불사성적안액능명현감경당뇨병합병백내장환자술전염성반응，제고기항양화수평。
Objective To investigate the effect of povidone iodine irrigation combined with levofloxacin eye drops on the inflammatory indexes, NO and antioxidant indices in serum and tear fluid of patients with diabetic cataract.Methods 50 cases of pati ents with diabetic cataract and admitted into the hospital during January 2013 to January 2015 were selected as the research objects all of whom received cataract surgery.According to the randomized double blind method, the patients were divided into two groups with 20 cases in each group.The control group received levofloxacin eye drops intervention before surgery while the observation group were treated withpovidone iodine irrigation, based on the control group.The inflammatory indexes (IL-2, sIL-2R, IL-6), NO, antioxidant indexes (TAC, SOD, CAT) and condition of postoperative infection were compared between the two groups before and after irrigation.ResuIts In the observation group, the sIL-2R, IL-6 and NO levels in serum and tear fluid after irrigation were significantly lower than those in the control group while IL-2, TAC, SOD and CAT were significantly higher than those in the control group.The differences were statistically significant (P<0.05).The postoperative infection rate of the observation group was 0.0% which was significantly lower than 16.0% of the control group.The difference was statistically significant ( P<0.05 ) .ConcIusion Povidone iodine irrigation combined with levofloxacin eye drops can significantly reduce the inflammatory reactions in patients with diabetic cataract and improve their antioxidant level.
