CAJ | 학술논문

目的：探讨大豆磷脂对脑卒中患者hs－CRP及血脂的影响。方法选取南昌市第一医院2014年3月～2015年6月的确诊为急性缺血性脑卒中患者76例，根据随机数字表法随机分为2组：实验组38例，在基础治疗上联合大豆磷脂；对照组38例，予基础治疗。观察2组患者治疗前后血清hs－CRP、IL－6、Hcy及血脂的变化，探索大豆磷脂治疗急性缺血性脑卒中患者的疗效机制。结果与对照组比较，治疗后实验组患者血清中hs－CRP、IL－6及Hcy较低（P＜0．05），TC、TG及LDL－C较低（P＜0．05）， HDL－C较高（ P＜0．05），总有效率较高（ P＜0．05），且不良反应较低（ P＜0．05），其结果均有统计学意义。结论大豆磷脂能够明显降低患者血清中hs－CRP、IL－6及Hcy水平，改善血脂代谢，提高临床疗效，且不良反应轻微，对急性缺血性脑卒中患者具有重要意义。
목적：탐토대두린지대뇌졸중환자hs－CRP급혈지적영향。방법선취남창시제일의원2014년3월～2015년6월적학진위급성결혈성뇌졸중환자76례，근거수궤수자표법수궤분위2조：실험조38례，재기출치료상연합대두린지；대조조38례，여기출치료。관찰2조환자치료전후혈청hs－CRP、IL－6、Hcy급혈지적변화，탐색대두린지치료급성결혈성뇌졸중환자적료효궤제。결과여대조조비교，치료후실험조환자혈청중hs－CRP、IL－6급Hcy교저（P＜0．05），TC、TG급LDL－C교저（P＜0．05）， HDL－C교고（ P＜0．05），총유효솔교고（ P＜0．05），차불량반응교저（ P＜0．05），기결과균유통계학의의。결론대두린지능구명현강저환자혈청중hs－CRP、IL－6급Hcy수평，개선혈지대사，제고림상료효，차불량반응경미，대급성결혈성뇌졸중환자구유중요의의。
Objective To investigate the effect of granulesten on hs-CRP and lipid in patients with stroke.Methods 76 patients with acute ischemic stroke were selected and randomly divided into two groups.38 cases in the control group were treated by conventional therapy, 38 cases in the experiment group were treated on the basis of the control group with granulesten.hs-CRP, IL-6, Hcy, and lipid fat were detected and the clinic effect were compared after the treatment.ResuIt Compared with control group, hs-CRP, IL-6, and Hcy of the experiment group were lower(P<0.05), TC, TG and LDL-C were lower, HDL-C was higher ( P<0.05 ) , the clinic effect was higher ( P<0.05 ) , the rate of side effect was higher ( P<0.05 ) . ConcIusion Granulester can significantly reduce serum hs-CRP, IL-6 and Hcy levels, improve blood lipid metabolism, improve the clinical efficacy, and adverse reactions are mild, it has important significance for patients with acute ischemic stroke.