CAJ | 학술논문

目的：观察封闭抗体阴性的早期流产患者在孕激素等常规治疗的基础上加用被动免疫治疗的效果。方法选取2012～2014年在广东省珠海市妇幼保健院80例确诊封闭抗体阴性的早孕保胎患者资料，将采用孕激素、人绒毛膜促性腺激素等常规保胎治疗患者40例纳入对照组，另40例在对照组基础上采用丙种免疫球蛋白治疗患者纳入观察组，比较两组患者的妊娠成功率。结果观察组继续妊娠至12周成功率为75.0％（30／40）．对照组继续妊娠至12周成功率为52.5％（21／40），两组比较差异有统计学意义（P＜0.05）。结论对于封闭抗体阴性的早期自然流产患者积极采用被动免疫治疗联合常规激素保胎治疗可提高妊娠成功率。
목적：관찰봉폐항체음성적조기유산환자재잉격소등상규치료적기출상가용피동면역치료적효과。방법선취2012～2014년재광동성주해시부유보건원80례학진봉폐항체음성적조잉보태환자자료，장채용잉격소、인융모막촉성선격소등상규보태치료환자40례납입대조조，령40례재대조조기출상채용병충면역구단백치료환자납입관찰조，비교량조환자적임신성공솔。결과관찰조계속임신지12주성공솔위75.0％（30／40）．대조조계속임신지12주성공솔위52.5％（21／40），량조비교차이유통계학의의（P＜0.05）。결론대우봉폐항체음성적조기자연유산환자적겁채용피동면역치료연합상규격소보태치료가제고임신성공솔。
Objective To study the effect of passive immunotherapy combined with conventional tocolytic therapy for the early abortion patients with negative blocking antibodies.Methods Clinical data of 80 early pregnancy tocolysis patients with negative blocking antibodies in Maternal and Child Health Hospital of Zhuhai City from 2012 to 2014 were selected,all cases were divided into observation group and control group with 40 cases in each group.The conventional tocolytic therapy such as progesterone and HCG injection were used in control group, on the basis of control group, gamma immunoglobulin were used in observation group.The pregnancy success rate of two groups were compared.Results The success rate of pregnancy to 12 weeks of observation group and control group were 75.0 %(30/40)and 52.5 % (21/40) respectively,the difference was significant between the two groups (P<0.05).Conclusion The combination of passive immunotherapy and hormonotherapy for the early spontaneous abortion patients with negative blocking antibodies can improve pregnancy success rate.