中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
7期
69-72
,共4页
α-酮酸%低蛋白饮食%肾功能%钙磷代谢%营养评估%腺苷脱氨酶
α-酮痠%低蛋白飲食%腎功能%鈣燐代謝%營養評估%腺苷脫氨酶
α-동산%저단백음식%신공능%개린대사%영양평고%선감탈안매
alpha keto acid%low protein diet%renal function%calcium-phosphorus metabolism%nutrition assessment%adenosine deaminase
目的:探讨α-酮酸配伍低蛋白饮食对长期腹膜透析营养不良患者肾脏功能、钙磷代谢及腺苷脱氨酶( adenosine deaminase,ADA)活性影响及其意义。方法选取2013年5月~2014年8月于海口市人民医院透析中心行长期腹膜透析患者46例,根据随机数字表法随机分为2组:对照组(n=23)予临床常规治疗,每天蛋白质摄入量为1.2 g/(kg? d);实验组(n=23)在常规治疗基础上应用α-酮酸配伍低蛋白饮食方案,每天蛋白质摄入量为0.8 g/( kg? d)。连续治疗3个月为一疗程。观察并比较2组患者血钙、血磷、营养状态、肾脏功能及腺苷脱氨酶活性变化。结果治疗3个月后,与对照组比较,实验组患者血肌酐、尿素氮、血尿酸较低(P<0.05);血钙水平较高(P<0.05),血磷水平较低(P<0.05),ADA活性和白细胞计数较低(P<0.05),但2组营养不良发生率比较,差异无统计学意义(χ2=3.136,P>0.05)。结论α-酮酸配伍低蛋白饮食能有效升高长期腹膜透析患者血钙水平、降低血磷水平,并能降低患者腺苷脱氨酶活性和白细胞计数,改善患者营养状态,对临床长期腹膜透析患者的治疗具有重要意义。
目的:探討α-酮痠配伍低蛋白飲食對長期腹膜透析營養不良患者腎髒功能、鈣燐代謝及腺苷脫氨酶( adenosine deaminase,ADA)活性影響及其意義。方法選取2013年5月~2014年8月于海口市人民醫院透析中心行長期腹膜透析患者46例,根據隨機數字錶法隨機分為2組:對照組(n=23)予臨床常規治療,每天蛋白質攝入量為1.2 g/(kg? d);實驗組(n=23)在常規治療基礎上應用α-酮痠配伍低蛋白飲食方案,每天蛋白質攝入量為0.8 g/( kg? d)。連續治療3箇月為一療程。觀察併比較2組患者血鈣、血燐、營養狀態、腎髒功能及腺苷脫氨酶活性變化。結果治療3箇月後,與對照組比較,實驗組患者血肌酐、尿素氮、血尿痠較低(P<0.05);血鈣水平較高(P<0.05),血燐水平較低(P<0.05),ADA活性和白細胞計數較低(P<0.05),但2組營養不良髮生率比較,差異無統計學意義(χ2=3.136,P>0.05)。結論α-酮痠配伍低蛋白飲食能有效升高長期腹膜透析患者血鈣水平、降低血燐水平,併能降低患者腺苷脫氨酶活性和白細胞計數,改善患者營養狀態,對臨床長期腹膜透析患者的治療具有重要意義。
목적:탐토α-동산배오저단백음식대장기복막투석영양불량환자신장공능、개린대사급선감탈안매( adenosine deaminase,ADA)활성영향급기의의。방법선취2013년5월~2014년8월우해구시인민의원투석중심행장기복막투석환자46례,근거수궤수자표법수궤분위2조:대조조(n=23)여림상상규치료,매천단백질섭입량위1.2 g/(kg? d);실험조(n=23)재상규치료기출상응용α-동산배오저단백음식방안,매천단백질섭입량위0.8 g/( kg? d)。련속치료3개월위일료정。관찰병비교2조환자혈개、혈린、영양상태、신장공능급선감탈안매활성변화。결과치료3개월후,여대조조비교,실험조환자혈기항、뇨소담、혈뇨산교저(P<0.05);혈개수평교고(P<0.05),혈린수평교저(P<0.05),ADA활성화백세포계수교저(P<0.05),단2조영양불량발생솔비교,차이무통계학의의(χ2=3.136,P>0.05)。결론α-동산배오저단백음식능유효승고장기복막투석환자혈개수평、강저혈린수평,병능강저환자선감탈안매활성화백세포계수,개선환자영양상태,대림상장기복막투석환자적치료구유중요의의。
Objective To investigate the effect of α-keto acid combined with low protein diet on kidney function, calcium-phosphorus metabolism and adenosine deaminase activity in malnourished patients with long term peritoneal dialysis.Methods Forty-six cases malnourished patients with long term peritoneal dialysis were selected from May 2013 to August 2014 in the hospital and divided into two groups.The control group (n=23) were treated by conventional therapy, acceptable daily intake of protein 1.2 g/(kg? d).The experiment group (n=23) were treated by α-keto acid combined with low protein diet, acceptable daily intake of protein 0.8 g/(kg? d).Two groups were treated for three months.Serum calcium, phosphorus, nutritional status assessment, adenosine deaminase activity and renal function were observed and compared after treatment.ResuIts After twelve months ’ treatment, compared with control group, serum creatinine, blood urea nitrogen, serum uric acid of experiment group were lower ( P<0.05); serum calcium level was higher (P<0.05), serum phosphorus level was lower (P<0.05);ADA activity and white blood cell count were lower (P<0.05). The incidence of malnutrition rate had no significant difference between two groups(χ2 =3.136,P>0.05).ConcIusion α-keto acid combined with low protein diet could effectively increase serum calcium level, reduce serum phosphorus level, ADA activity and WBC count, and improve nutritional status in long-term peritoneal dialysis patients, which has important significance.