CAJ | 학술논문

目的：探讨利拉鲁肽联合胰岛素治疗对1型糖尿病患者糖化血红蛋白、T淋巴细胞亚群及胰岛功能的影响。方法收集唐山市中医医院收治的1型糖尿病患者46例，随机分为对照组和实验组，每组各23例。对照组根据患者的血糖水平给予重组人胰岛素控制血糖，实验组在对照组基础上予以利拉鲁肽治疗。治疗结束后，对所有患者的血清糖化血红蛋白、T淋巴细胞亚群、C肽（C－Peptide，CP）以及血糖水平进行检测。结果治疗后与对照组相比，实验组患者的血清糖化血红蛋白水平较低（P＜0．05）；CD4＋T水平较高、CD8＋T水平较低、CD4＋／CD8＋T比值较高（P＜0．05）；实验组患者的空腹血糖（fasting plasma glucose，FPG）、餐后2 h血糖（2－hour postprandial blood glucose，2 hPG）水平较低，CP、餐后2 hC肽（2－hour postprandial C－Peptide，2 hCP）水平较高（P＜0．05）。2组患者肝肾功能比较差异无统计学意义。结论利拉鲁肽联合胰岛素治疗能够显著降低1型糖尿病患者血清糖化血红蛋白水平、上升CD4＋T水平、降低CD8＋T水平，改善血糖水平，从而改善其胰岛功能。
목적：탐토리랍로태연합이도소치료대1형당뇨병환자당화혈홍단백、T림파세포아군급이도공능적영향。방법수집당산시중의의원수치적1형당뇨병환자46례，수궤분위대조조화실험조，매조각23례。대조조근거환자적혈당수평급여중조인이도소공제혈당，실험조재대조조기출상여이리랍로태치료。치료결속후，대소유환자적혈청당화혈홍단백、T림파세포아군、C태（C－Peptide，CP）이급혈당수평진행검측。결과치료후여대조조상비，실험조환자적혈청당화혈홍단백수평교저（P＜0．05）；CD4＋T수평교고、CD8＋T수평교저、CD4＋／CD8＋T비치교고（P＜0．05）；실험조환자적공복혈당（fasting plasma glucose，FPG）、찬후2 h혈당（2－hour postprandial blood glucose，2 hPG）수평교저，CP、찬후2 hC태（2－hour postprandial C－Peptide，2 hCP）수평교고（P＜0．05）。2조환자간신공능비교차이무통계학의의。결론리랍로태연합이도소치료능구현저강저1형당뇨병환자혈청당화혈홍단백수평、상승CD4＋T수평、강저CD8＋T수평，개선혈당수평，종이개선기이도공능。
Objective To investigate the effect of liraglutide combined with insulin on the HbA1c, T lymphocyte subsets and islet function in patients with type 1 diabetes.Methods 46 cases from endocrinology department of Tangshan Traditional Chinese Medicine Hospital with type 1 diabetes were selected and randomly divided into two groups each group had 23 patients.Control group were given recombinant human insulin to control blood sugar according to the blood glucose level, and experimental group were given liraglutide on the basis of control group.HbA1c, T lymphocyte subsets, C-Peptide ( CP) and islet function were compared after treatment.ResuIts Compared with control group after treatment, HBAlc level in experimental group was lower (P<0.05); CD4 +T was higher, CD8 +T was lower, and CD4 +/CD8 +T was higher (P<0.05); the fasting plasma glucose (FPG) level was lower (P<0.05);2-hour postprandial blood glucose (2 hPG) was lower (P<0.05); CP and 2-hour postprandial C-Peptide (2 hCP) were higher (P<0.05).There was no significant difference in liver and kidney function between two groups.ConcIusion Liraglutide combined with insulin could significantly reduce serum glycated hemoglobin level, increase CD4 +T level and reduce CD8 +T level, improve islet function in patients with type 1 diabetic.