中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
7期
63-65
,共3页
下肢动脉硬化闭塞症%益气活血化痰通络汤%前列地尔%临床疗效
下肢動脈硬化閉塞癥%益氣活血化痰通絡湯%前列地爾%臨床療效
하지동맥경화폐새증%익기활혈화담통락탕%전렬지이%림상료효
lower extremity arterial occlusive disease%Yiqi Huoxue Huatan Tongluo Decoction%alprostadil%clinical effect
目的：观察前列地尔联合益气活血化痰通络汤治疗下肢动脉硬化闭塞症的临床疗效。方法将60例下肢动脉硬化闭塞症门诊及住院患者按照随机数字表法随机分为治疗组与对照组，每组各30例，将口服肠溶阿司匹林的实验组设为对照组，静脉输注前列地尔，治疗组则是在对照组的基础上加用化痰通络汤，疗程为4周。观察2组患者观察患者的临床症状、血管功能[踝肱指数（ ankle－brachial index，ABI）]、低密度脂蛋白胆固醇（ low density lipoprotein－cholesterol，LDL－C）、血清总胆固醇（ total cholesterol， TC），血液流变学指标包括全血粘度、纤维原蛋白、肝肾功能及不良反应。结果治疗组总有效率为93．33％优于对照组的73．33％（ P＜0．05），治疗组踝肱指数（ ABI）改善优于对照组，治疗组TC、LDL－C、高切全血粘度、低切全血粘度、纤维原蛋白改善均优于对照组（均P＜0．05）。结论活血化痰通络方联合前列地尔治疗下肢动脉硬化闭塞症疗效优于单纯前列地尔治疗。
目的：觀察前列地爾聯閤益氣活血化痰通絡湯治療下肢動脈硬化閉塞癥的臨床療效。方法將60例下肢動脈硬化閉塞癥門診及住院患者按照隨機數字錶法隨機分為治療組與對照組，每組各30例，將口服腸溶阿司匹林的實驗組設為對照組，靜脈輸註前列地爾，治療組則是在對照組的基礎上加用化痰通絡湯，療程為4週。觀察2組患者觀察患者的臨床癥狀、血管功能[踝肱指數（ ankle－brachial index，ABI）]、低密度脂蛋白膽固醇（ low density lipoprotein－cholesterol，LDL－C）、血清總膽固醇（ total cholesterol， TC），血液流變學指標包括全血粘度、纖維原蛋白、肝腎功能及不良反應。結果治療組總有效率為93．33％優于對照組的73．33％（ P＜0．05），治療組踝肱指數（ ABI）改善優于對照組，治療組TC、LDL－C、高切全血粘度、低切全血粘度、纖維原蛋白改善均優于對照組（均P＜0．05）。結論活血化痰通絡方聯閤前列地爾治療下肢動脈硬化閉塞癥療效優于單純前列地爾治療。
목적：관찰전렬지이연합익기활혈화담통락탕치료하지동맥경화폐새증적림상료효。방법장60례하지동맥경화폐새증문진급주원환자안조수궤수자표법수궤분위치료조여대조조，매조각30례，장구복장용아사필림적실험조설위대조조，정맥수주전렬지이，치료조칙시재대조조적기출상가용화담통락탕，료정위4주。관찰2조환자관찰환자적림상증상、혈관공능[과굉지수（ ankle－brachial index，ABI）]、저밀도지단백담고순（ low density lipoprotein－cholesterol，LDL－C）、혈청총담고순（ total cholesterol， TC），혈액류변학지표포괄전혈점도、섬유원단백、간신공능급불량반응。결과치료조총유효솔위93．33％우우대조조적73．33％（ P＜0．05），치료조과굉지수（ ABI）개선우우대조조，치료조TC、LDL－C、고절전혈점도、저절전혈점도、섬유원단백개선균우우대조조（균P＜0．05）。결론활혈화담통락방연합전렬지이치료하지동맥경화폐새증료효우우단순전렬지이치료。
Objective To observe the clinical effect of alprostadil combined with Yiqi Huoxue Huatan Tongluo Decoction in treating arteriosclerosis obliterans.Methods 60 cases of lower extremity arteriosclerosis occlusion disease outpatient and hospitalized patients were randomly divided into treatment group and control group according to the random number table method, each group were 30, the oral administration of enteric coated aspirin experimental group is set to control group intravenous injection of alprostadil treatment for 4 weeks, the treatment group was treated with Huatan Tongluo Decoction on the basis of the control group.The clinical symptoms, blood vessel function (ABI),low density lipoprotein-cholesterol (LDL-C), total cholesterol( TC) were observed in the two groups of patients, and blood rheology indexes included whole blood viscosity, fibrinogen, liver and kidney function and adverse reactions.ResuIts Total effective rate of the treatment group was 93.33% than control group 73.33% (P<0.05), the treatment group of ankle brachial index ( ABI) was better than the control group, the treatment group TC, LDL-C, high shear whole blood viscosity, low shear whole blood viscosity, fibrinogen protein improve were better than those of the control group (P<0.05).ConcIusion Disease curative effect is better than pure alprostadil in the treatment of occlusion Huoxue Huatan Tongluo Decoction combined with alprostadil in the treatment of lower limb arteriosclerosis.
