CAJ | 학술논문

目的：探讨百令胶囊联合西黄丸对Ⅲ期乳腺癌患者ER、MMP－9、肿瘤标志物及雌激素影响。方法选取已确诊为Ⅲ期乳腺癌的患者76例，采用随机数字表将患者随机分为实验组和对照组，对照组予临床常规方法治疗，实验组在与对照组相同的临床常规方法治疗基础上加用百令胶囊联合西黄丸治疗，疗程8周。观察2组患者ER、MMP－9、肿瘤标志物及雌激素及生存时间和生活质量。结果与对照组相比，实验组患者生存期均长于对照组（ P＜0．05）；实验组患者生活质量评分高于对照组（ P＜0．05）， ER、MMP－9、E2、E1水平低于对照组（P＜0．05），血清CA15－3、CA125、CEA表达水平低于对照组（P＜0．05）。结论百令胶囊联合西黄丸能有效降低Ⅲ期乳腺癌患者肿瘤标志物水平，降低ER、MMP－9表达及雌激素水平，延长生存时间、提高生活质量，对临床治疗Ⅲ期乳腺癌具有重要意义。
목적：탐토백령효낭연합서황환대Ⅲ기유선암환자ER、MMP－9、종류표지물급자격소영향。방법선취이학진위Ⅲ기유선암적환자76례，채용수궤수자표장환자수궤분위실험조화대조조，대조조여림상상규방법치료，실험조재여대조조상동적림상상규방법치료기출상가용백령효낭연합서황환치료，료정8주。관찰2조환자ER、MMP－9、종류표지물급자격소급생존시간화생활질량。결과여대조조상비，실험조환자생존기균장우대조조（ P＜0．05）；실험조환자생활질량평분고우대조조（ P＜0．05）， ER、MMP－9、E2、E1수평저우대조조（P＜0．05），혈청CA15－3、CA125、CEA표체수평저우대조조（P＜0．05）。결론백령효낭연합서황환능유효강저Ⅲ기유선암환자종류표지물수평，강저ER、MMP－9표체급자격소수평，연장생존시간、제고생활질량，대림상치료Ⅲ기유선암구유중요의의。
Objective To investigate effect of Bailing Capsule combined with Xihuangwan in stage III breast cancer patients of ER, MMP-9, tumor markers and estrogen.Methods 76 Patients with stage III breast cancer were selected and divided into control group anf experiment group.Control group were treated by clinical routine method.Experiment group were treated on the base of the control group with Bailing Capsule combined with Xihuangwan.The ER, MMP-9, tumor markers, estrogen, survival time and quality of life were observed and compared.ResuIts Compared with control group, the survival period of the experiment group were longer(P<0.05),the quality of life score were higher(P<0.05),the ER, MMP-9, E2, E1 level and the serum levels of CA15-3, CA125 and CEA were lower(P<0.05).ConcIusion Bailing capsule combined with Xihuang Pill can effectively reduce stage III breast cancer tumor marker levels, decrease the ER, the expression of MMP-9 and estrogen level and prolong survival time, improve the quality of life, has the vital significance to the clinical therapy for stage III breast cancer.