中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
7期
57-59
,共3页
向光俊%杨洪政%黄晶%彭毅志
嚮光俊%楊洪政%黃晶%彭毅誌
향광준%양홍정%황정%팽의지
Rho激酶%生脉注射液%浅二度烧伤%肿瘤坏死因子α%白细胞介素-10%细胞间粘附分子-1%CD11/CD18
Rho激酶%生脈註射液%淺二度燒傷%腫瘤壞死因子α%白細胞介素-10%細胞間粘附分子-1%CD11/CD18
Rho격매%생맥주사액%천이도소상%종류배사인자α%백세포개소-10%세포간점부분자-1%CD11/CD18
Rho kinase%Sheng Mai injection%Ⅱ°superficial burn%tumor necrosis factor alpha%interleukin-10%intercellular adhesion molecule-1%CD11/CD18
目的：探讨Rho激酶联合生脉注射液对浅二度烧伤患者外周血肿瘤坏死因子α（ tumor necrosis factor alpha，TNF－α）、白细胞介素－10（interleukin－10，IL－10）、细胞间粘附分子－1（intercellular adhesion molecule－1，ICAM－1）及粘附分子CD11／CD18水平的影响。方法收集三峡大学仁和医院收治的浅二度烧伤住院患者48例，根据用药不同分为对照组和实验组，每组各24例，2组患者均给予抗伤口感染、保暖、抗休克、止痛、促进伤口愈合等对症治疗，对照组患者在此基础上给予Rho激酶糖治疗，实验组在对照组的基础上给予生脉注射液，连续治疗2周。治疗结束后，对患者血清TNF－α、IL－10、ICAM－1及CD11／CD18水平进行比较。结果与治疗前相比，治疗后2组患者的血清TNF－α、IL－10、ICAM－1、CD11／CD18水平均显著降低（ P＜0．05）。治疗后，与对照组相比，实验组患者的TNF－α、IL－10、ICAM－1、CD11／CD18水平较低（P＜0．05）。结论 Rho激酶联合生脉注射液能够显著降低浅二度烧伤患者的TNF－α、IL－10、ICAM－1以及CD11／CD18水平，对临床有指导意义。
目的：探討Rho激酶聯閤生脈註射液對淺二度燒傷患者外週血腫瘤壞死因子α（ tumor necrosis factor alpha，TNF－α）、白細胞介素－10（interleukin－10，IL－10）、細胞間粘附分子－1（intercellular adhesion molecule－1，ICAM－1）及粘附分子CD11／CD18水平的影響。方法收集三峽大學仁和醫院收治的淺二度燒傷住院患者48例，根據用藥不同分為對照組和實驗組，每組各24例，2組患者均給予抗傷口感染、保暖、抗休剋、止痛、促進傷口愈閤等對癥治療，對照組患者在此基礎上給予Rho激酶糖治療，實驗組在對照組的基礎上給予生脈註射液，連續治療2週。治療結束後，對患者血清TNF－α、IL－10、ICAM－1及CD11／CD18水平進行比較。結果與治療前相比，治療後2組患者的血清TNF－α、IL－10、ICAM－1、CD11／CD18水平均顯著降低（ P＜0．05）。治療後，與對照組相比，實驗組患者的TNF－α、IL－10、ICAM－1、CD11／CD18水平較低（P＜0．05）。結論 Rho激酶聯閤生脈註射液能夠顯著降低淺二度燒傷患者的TNF－α、IL－10、ICAM－1以及CD11／CD18水平，對臨床有指導意義。
목적：탐토Rho격매연합생맥주사액대천이도소상환자외주혈종류배사인자α（ tumor necrosis factor alpha，TNF－α）、백세포개소－10（interleukin－10，IL－10）、세포간점부분자－1（intercellular adhesion molecule－1，ICAM－1）급점부분자CD11／CD18수평적영향。방법수집삼협대학인화의원수치적천이도소상주원환자48례，근거용약불동분위대조조화실험조，매조각24례，2조환자균급여항상구감염、보난、항휴극、지통、촉진상구유합등대증치료，대조조환자재차기출상급여Rho격매당치료，실험조재대조조적기출상급여생맥주사액，련속치료2주。치료결속후，대환자혈청TNF－α、IL－10、ICAM－1급CD11／CD18수평진행비교。결과여치료전상비，치료후2조환자적혈청TNF－α、IL－10、ICAM－1、CD11／CD18수평균현저강저（ P＜0．05）。치료후，여대조조상비，실험조환자적TNF－α、IL－10、ICAM－1、CD11／CD18수평교저（P＜0．05）。결론 Rho격매연합생맥주사액능구현저강저천이도소상환자적TNF－α、IL－10、ICAM－1이급CD11／CD18수평，대림상유지도의의。
Objective To investigate effect of Rho kinase combined with Sheng Mai injection on tumor necrosis factor alpha ( TNF-α) , interleukin-10 (IL-10), intercellular adhesion molecule-1 (ICAM-1) and adhesion molecule CD11/CD18 in patients withⅡ°superficial burn.Methods 48 cases patients withⅡ°superficial burn were collected and divided into experimental group and control group, according to different therapy, 24 cases in each group.The two groups were given symptomatic treatment such as anti-infectious, keep warm, anti-shock, pain-relieve and wound-healing treatment, the control group were given Rho kinase on the basis of symptomatic treatment, and experimental group were given Sheng Mai injection on the basis of control group, for a course of two weeks.The serum TNF-α, IL-10, ICAM-1 and CD11/CD18 levels were compared after treatment. ResuIts After treatment, the serum TNF-α, IL-10, ICAM-1 and CD11/CD18 levels after treatment were lower than those before treatment in two groups (P<0.05).Compared with control group, the levels of TNF-α, IL-10, ICAM-1 and CD11/CD18 were lower than those of experimental group (P<0.05).ConcIusion Rho kinase combined with Sheng Mai injection could significantly reduce the levels of TNF-α, IL-10, ICAM-1 and CD11/CD18 in patients with Ⅱ°superficial burn.
