中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2015年
7期
47-49,52
,共4页
王丽晔%刘运秋%耿贺梅%郑丽颖%王瑞霞%修春霞
王麗曄%劉運鞦%耿賀梅%鄭麗穎%王瑞霞%脩春霞
왕려엽%류운추%경하매%정려영%왕서하%수춘하
睡眠呼吸暂停综合症%枸橼酸咖啡因%肺功能%VEGF%胰岛素样生长因子
睡眠呼吸暫停綜閤癥%枸櫞痠咖啡因%肺功能%VEGF%胰島素樣生長因子
수면호흡잠정종합증%구연산가배인%폐공능%VEGF%이도소양생장인자
sleep apnea hypopnea syndrome%caffeine citrate%pulmonary function%VEGF%insulin-like growth factor
目的:探讨枸橼酸咖啡因对睡眠呼吸暂停综合症大鼠肺功能、血管内皮细胞生长因子( VEGF)与胰岛素样生长因子-1( IGF-1)的影响。方法选取睡眠呼吸暂停综合症模型Wistar雄性大鼠80只,随机选取20只为正常对照组,其余进行呼吸暂停综合征模型复制,模型复制成功后,随机分为模型组20只,实验组20只和阳性药组20只,实验组予枸橼酸咖啡因注射液5 mg/kg腹腔注射,阳性药组给予氨茶碱3 mg/kg腹腔注射,模型组等量生理盐水腹腔注射,每天1次,连续1周;干预结束后,比较各组大鼠的肺功能相关指标、血清VEGF、IGF-1含量及睡眠呼吸暂停相关指标。结果与阳性药组比较,实验组大鼠肺功能相关指标明显升高( P<0.05);血清VEGF水平明显降低(P<0.05);血清IGF-1水平明显升高(P<0.05);NREM期及REM期的睡眠呼吸暂停指数明显下降( P<0.05)。结论枸橼酸咖啡因能够改善睡眠呼吸暂停综合症大鼠的肺功能,降低其血清VEGF水平,促进血清IGF-1的生成,使睡眠呼吸暂停指数降低。
目的:探討枸櫞痠咖啡因對睡眠呼吸暫停綜閤癥大鼠肺功能、血管內皮細胞生長因子( VEGF)與胰島素樣生長因子-1( IGF-1)的影響。方法選取睡眠呼吸暫停綜閤癥模型Wistar雄性大鼠80隻,隨機選取20隻為正常對照組,其餘進行呼吸暫停綜閤徵模型複製,模型複製成功後,隨機分為模型組20隻,實驗組20隻和暘性藥組20隻,實驗組予枸櫞痠咖啡因註射液5 mg/kg腹腔註射,暘性藥組給予氨茶堿3 mg/kg腹腔註射,模型組等量生理鹽水腹腔註射,每天1次,連續1週;榦預結束後,比較各組大鼠的肺功能相關指標、血清VEGF、IGF-1含量及睡眠呼吸暫停相關指標。結果與暘性藥組比較,實驗組大鼠肺功能相關指標明顯升高( P<0.05);血清VEGF水平明顯降低(P<0.05);血清IGF-1水平明顯升高(P<0.05);NREM期及REM期的睡眠呼吸暫停指數明顯下降( P<0.05)。結論枸櫞痠咖啡因能夠改善睡眠呼吸暫停綜閤癥大鼠的肺功能,降低其血清VEGF水平,促進血清IGF-1的生成,使睡眠呼吸暫停指數降低。
목적:탐토구연산가배인대수면호흡잠정종합증대서폐공능、혈관내피세포생장인자( VEGF)여이도소양생장인자-1( IGF-1)적영향。방법선취수면호흡잠정종합증모형Wistar웅성대서80지,수궤선취20지위정상대조조,기여진행호흡잠정종합정모형복제,모형복제성공후,수궤분위모형조20지,실험조20지화양성약조20지,실험조여구연산가배인주사액5 mg/kg복강주사,양성약조급여안다감3 mg/kg복강주사,모형조등량생리염수복강주사,매천1차,련속1주;간예결속후,비교각조대서적폐공능상관지표、혈청VEGF、IGF-1함량급수면호흡잠정상관지표。결과여양성약조비교,실험조대서폐공능상관지표명현승고( P<0.05);혈청VEGF수평명현강저(P<0.05);혈청IGF-1수평명현승고(P<0.05);NREM기급REM기적수면호흡잠정지수명현하강( P<0.05)。결론구연산가배인능구개선수면호흡잠정종합증대서적폐공능,강저기혈청VEGF수평,촉진혈청IGF-1적생성,사수면호흡잠정지수강저。
Objective To analysis the effect of caffeine citrate on pulmonary function, vascular endothelial growth factor (VEGF)and insulin like growth factor -1 (IGF-1) in the apnea syndrome rats.Methods 80 male Wistar rats were selected, 20 were randomly selected to be the control group, the rest of the rats were replicated of apnea syndrome model.The rats were randomly divided into model group, experiment group and positive drug group, 20 of each group.The experimental group was given caffeine citrate injection of 5 mg/kg intraperitoneal injection, the positive drug group was given intraperitoneal injection of aminophylline 3 mg/kg, the model group was given intraperitoneal injection of normal saline, once a day, continuously for 1 week.Pulmonary function, serum VEGF, IGF-1 levels and sleep apnea were compared after the experiment.ResuIts Compared with the positive drug group, the related indexes of pulmonary function of the experimental group increased significantly ( P<0.05 ) .Serum VEGF levels decreased significantly (P<0.05).The serum IGF-1 level increased significantly (P<0.05).The sleep apnea index decreased significantly during the period of NREM and REM.(P<0.05).ConcIusion Caffeine citrate can improve apnea syndrome rats lung function, reduce the serum VEGF level, promote the formation of serum IGF-1, reduce the sleep apnea index.