实用中医药杂志
實用中醫藥雜誌
실용중의약잡지
JOURNAL OF PRACTICAL TRADITIONAL CHINESE MEDICINE
2015年
8期
700-701,702
,共3页
刘伟伟%张亮%张丽%孙响波%张法荣
劉偉偉%張亮%張麗%孫響波%張法榮
류위위%장량%장려%손향파%장법영
黑地黄丸%5/6肾切除大鼠肾衰模型%血清BUN%Scr%影响
黑地黃汍%5/6腎切除大鼠腎衰模型%血清BUN%Scr%影響
흑지황환%5/6신절제대서신쇠모형%혈청BUN%Scr%영향
Heidihuang Pills%5/6 nephrectomized rats%serum BUN and Scr%effect
目的：观察黑地黄丸对5/6肾切除大鼠肾衰（CRF大鼠）模型的血清尿素、肌酐水平的影响。方法：70只Wistar大鼠随机分为空白组，模型组，黑地黄丸高、中、低剂量组，尿毒清组，洛丁新组。除空白组外其他各组大鼠均行5/6肾切除术，建立CRF大鼠模型，连续给药12周后，采用酶偶联速率法测定血清尿素及采用碱性苦味酸法测定血清肌酐动脉含量。结果：与模型组比较，黑地黄丸高、中、低剂量组血清BUN、Scr降低显著（P＜0.01）。与黑地黄丸低剂量组比较，黑地黄丸高剂量组、尿毒清组血清BUN降低（P＜0.05）。与黑地黄丸低剂量组比较，黑地黄丸高剂量组、尿毒清组血清Scr降低显著（P＜0.01）。结论：黑地黄丸可以明显降低肾衰大鼠的血清BUN、Scr，从而改善肾功能，延缓CRF进程，尤以黑地黄丸高剂量效果最佳。
目的：觀察黑地黃汍對5/6腎切除大鼠腎衰（CRF大鼠）模型的血清尿素、肌酐水平的影響。方法：70隻Wistar大鼠隨機分為空白組，模型組，黑地黃汍高、中、低劑量組，尿毒清組，洛丁新組。除空白組外其他各組大鼠均行5/6腎切除術，建立CRF大鼠模型，連續給藥12週後，採用酶偶聯速率法測定血清尿素及採用堿性苦味痠法測定血清肌酐動脈含量。結果：與模型組比較，黑地黃汍高、中、低劑量組血清BUN、Scr降低顯著（P＜0.01）。與黑地黃汍低劑量組比較，黑地黃汍高劑量組、尿毒清組血清BUN降低（P＜0.05）。與黑地黃汍低劑量組比較，黑地黃汍高劑量組、尿毒清組血清Scr降低顯著（P＜0.01）。結論：黑地黃汍可以明顯降低腎衰大鼠的血清BUN、Scr，從而改善腎功能，延緩CRF進程，尤以黑地黃汍高劑量效果最佳。
목적：관찰흑지황환대5/6신절제대서신쇠（CRF대서）모형적혈청뇨소、기항수평적영향。방법：70지Wistar대서수궤분위공백조，모형조，흑지황환고、중、저제량조，뇨독청조，락정신조。제공백조외기타각조대서균행5/6신절제술，건립CRF대서모형，련속급약12주후，채용매우련속솔법측정혈청뇨소급채용감성고미산법측정혈청기항동맥함량。결과：여모형조비교，흑지황환고、중、저제량조혈청BUN、Scr강저현저（P＜0.01）。여흑지황환저제량조비교，흑지황환고제량조、뇨독청조혈청BUN강저（P＜0.05）。여흑지황환저제량조비교，흑지황환고제량조、뇨독청조혈청Scr강저현저（P＜0.01）。결론：흑지황환가이명현강저신쇠대서적혈청BUN、Scr，종이개선신공능，연완CRF진정，우이흑지황환고제량효과최가。
Objective:To observe the effect of Heidihuang Pills on the level of serum urea and creatinine in renal failure model of 5/6 nephrectomized rats. Method: 70 Wistar rats were divided into 7 groups randomly, the blank group, the model group, high dosage, middle dosage and low dosage of Heidihuang Pills groups, Niaoduqing group and Lotensin group. Every group were taken 5/6 nephrectomy except the blank group. CRF rat models were founded and given successive administration 12 d, then the content of serum urea was detected by the method of enzyme coupling ratio and serum creatinine was detected by basic picric acid method. Result: Compared with that of the control group, the level of serum BUN and Scr of high dosage, middle dosage and low dosage of Heidihuang Pills groups decreased significantly(P<0.01). Compared with that of low dosage of Heidihuang Pills group, the level of serum BUN of high dosage of Heidihuang Pills group and Niaoduqing group decreased(P<0.05). Compared with that of low dosage of Heidihuang Pills group, the level of serum Scr of high dosage of Heidihuang Pills group and Niaoduqing group decreased significantly(P<0.01). Conclusion: Heidihuang Pills, especially high dosage of Heidihuang Pills could achieve the best effect on decreasing serum BUN and Scr in renal failure rats obviously to improve the renal function and delay the progress of CRF.
