CAJ | 학술논문

目的了解新疆乌鲁木齐市居民甲状腺疾病知晓率及年龄分布的差异,分析甲状腺功能、甲状腺自身抗体与尿碘相关性及其变化规律.方法 2013年5月采用横断面方法随机抽取乌鲁木齐市1 995名常住居民,其中健康成年人1 906名,年龄18 ～ 84岁,平均(46.3±14.2)岁,男性占30.4％,女性占69.6％.采集一次性随机晨尿10 ml测定尿碘,静脉血测定促甲状腺素(TSH)、血清游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb).结果 (1)调查居民中新诊断甲状腺功能异常者213例(11.2％,其中女性占78.4％),甲状腺功能亢进(甲亢)者占2.7％,甲状腺功能减低(甲减)者占8.5％;TgAb阳性率为23.2％,TPOAb阳性率为16.6％;人群尿碘M=134.5 μg/L,人群中碘缺乏占32％,碘适宜占58％,碘过量占10％;甲状腺功能正常组和异常组比较、抗体阳性组与阴性组比较其尿碘水平的差异均无统计学意义.(2)将人群划分18～、45～和≥60岁3个年龄组,则显示随年龄增长TSH水平有明显差异,且女性高于男性(P＜0.001);甲状腺功能正常人群中,TSH水平为抗体阳性组明显高于阴性组(P＜0.000 1).(3)≥60岁与＜60岁人群比较,甲减患病率显著增加(P=0.008),但甲亢患病率无明显差别,抗体阳性率亦无明显差异.结论乌鲁木齐市社区居民甲状腺功能、自身抗体与尿碘水平无明显相关,女性甲状腺功能异常、抗体阳性率均高于男性,抗体阳性组TSH水平明显高于阴性组,老年人群甲减患病率显著增高,应对该人群定期监测.
목적 료해신강오로목제시거민갑상선질병지효솔급년령분포적차이,분석갑상선공능、갑상선자신항체여뇨전상관성급기변화규률.방법 2013년5월채용횡단면방법수궤추취오로목제시1 995명상주거민,기중건강성년인1 906명,년령18 ～ 84세,평균(46.3±14.2)세,남성점30.4％,녀성점69.6％.채집일차성수궤신뇨10 ml측정뇨전,정맥혈측정촉갑상선소(TSH)、혈청유리갑상선소(FT4)、유리삼전갑상선원안산(FT3)、갑상선구단백항체(TgAb)、갑상선과양화물매항체(TPOAb).결과 (1)조사거민중신진단갑상선공능이상자213례(11.2％,기중녀성점78.4％),갑상선공능항진(갑항)자점2.7％,갑상선공능감저(갑감)자점8.5％;TgAb양성솔위23.2％,TPOAb양성솔위16.6％;인군뇨전M=134.5 μg/L,인군중전결핍점32％,전괄의점58％,전과량점10％;갑상선공능정상조화이상조비교、항체양성조여음성조비교기뇨전수평적차이균무통계학의의.(2)장인군화분18～、45～화≥60세3개년령조,칙현시수년령증장TSH수평유명현차이,차녀성고우남성(P＜0.001);갑상선공능정상인군중,TSH수평위항체양성조명현고우음성조(P＜0.000 1).(3)≥60세여＜60세인군비교,갑감환병솔현저증가(P=0.008),단갑항환병솔무명현차별,항체양성솔역무명현차이.결론 오로목제시사구거민갑상선공능、자신항체여뇨전수평무명현상관,녀성갑상선공능이상、항체양성솔균고우남성,항체양성조TSH수평명현고우음성조,노년인군갑감환병솔현저증고,응대해인군정기감측.
Objective To understand the rates of diagnosis on thyroid disease and the differences in the distribution of age groups among those permanent residents,to analyze the relationships among thyroid function,thyroid antibodies and urinary iodine.Methods A cross-sectional survey was performed in 1 995 permanent residents in Urumqi,Xinjiang in May,2013,Among them,1 906 were healthy adults aged 18-84 age,with mean age as (46.3±14.2) years and 30.4％ of them were men.One time 10 ml random urine and blood samples were drown to examine urinary iodine (UI) thyroid stimulating hormone (TSH),free thyroxine (FT4),free triiodothyronine (FT3),anti-thyroglobulin (TgAb) and anti-thyroid peroxidase (TPOAb).Results 1) 213 residents were newly diagnosed as having thyroid dysfunction (11.2％,including 78.4％ women),hyperthyroidism (clinical and subclinical hyperthyroidism) that accounted for 2.7％,hypothyroidism (clinical and subclinical hypothyroidism) was accounted for 8.5％.Positive rates of TgAb (23.2％),TPOAb (16.6％) were noticed.The median urinary iodine was 134.5 μg/L,with 32％ of the subjects were having iodine deficiency,58％ having adequate iodine and another 10％ as under excessive iodine.No differences were observed on urine iodine between thyroid dysfunction and euthyroidism or between subjects with positive and negative antibodies.2) TSH appeared different among age-groups of 18-,45-and over 60.TSH showed higher in women than in men,with P value as ＜0.001.For people with euthyroidism,TSH level in the antibody positive group was significantly higher than the antibody negative group (P＜0.000 1).3) For people over 60 of age,morbidity of hypothyroidism was significantly higher than those under 60 but with no differences related to hyperthyroidism or the antibody positive rate.Conclusion UI levels were not significantly related with thyroid function and thyroid antibodies among residents of Urumqi,women showed higher on thyroid dysfunction or the rate of positive antibody.In the antibody positive group,TSH levels were significantly higher than in the antibody negative group.Hypothyroidism was seen higher in the over 60-years-of-age population.Monitoring programs on thyroid function,thyroid antibodies and urinary iodine among people over 60-years-of-age,should be strengthened.