CAJ | 학술논문

FoxO转录因子家族通过对其靶基因的调节作用，在细胞代谢、凋亡、增殖、应激反应、DNA修复和免疫应答等生命活动中发挥着重要作用。该家族成员FoxO3a可调控靶基因启动子发生组蛋白磷酸化、乙酰化、甲基化等修饰从而影响其表达。FoxO3a在泌尿系肿瘤中存在异常的低表达，其蛋白质修饰状态和活性受到以PI3K/Akt为主的多条信号通路的复杂调控，对泌尿系肿瘤的发生、发展和预后产生重要的影响。本文将对FoxO3a在泌尿系肿瘤中的研究进展进行综述，探讨FoxO3a调控的机制，为临床诊断和靶向治疗提供新的策略。
FoxO전록인자가족통과대기파기인적조절작용，재세포대사、조망、증식、응격반응、DNA수복화면역응답등생명활동중발휘착중요작용。해가족성원FoxO3a가조공파기인계동자발생조단백린산화、을선화、갑기화등수식종이영향기표체。FoxO3a재비뇨계종류중존재이상적저표체，기단백질수식상태화활성수도이PI3K/Akt위주적다조신호통로적복잡조공，대비뇨계종류적발생、발전화예후산생중요적영향。본문장대FoxO3a재비뇨계종류중적연구진전진행종술，탐토FoxO3a조공적궤제，위림상진단화파향치료제공신적책략。
The forkhead box O (FoxO) transcription factor family plays an important role in cell functions, including metabo-lism, apoptosis, cellular proliferation, stress reactions, DNA repair, and immune response. As a member of this family, forkhead box O3a (FoxO3a) regulates its target genes by modulating histone modifications, including phosphorylation, acetylation, and methylation. FoxO3a expression is abnormally downregulated in urologic neoplasm. Protein modifications and FoxO3a activity are mainly con-trolled by PI3K/Akt signal pathway and other signaling pathways. FoxO3a is also involved in the initiation, progression, and prognosis of urologic neoplasm. This review focuses on the function of FoxO3a in urologic neoplasm and elucidates the regulatory mechanisms involved. This article will provide novel strategies to clinical diagnosis and drug therapy of urologic neoplasms.