临床药物治疗杂志
臨床藥物治療雜誌
림상약물치료잡지
CLINICAL MEDICATION JOURNAL
2015年
4期
81-84
,共4页
黄金柱%罗晓%李咏%陈小红%卢来春
黃金柱%囉曉%李詠%陳小紅%盧來春
황금주%라효%리영%진소홍%로래춘
肾移植术后%阿奇霉素%伏立康唑%环孢素%药物相互作用
腎移植術後%阿奇黴素%伏立康唑%環孢素%藥物相互作用
신이식술후%아기매소%복립강서%배포소%약물상호작용
kidney transplantation%azithromycin%voriconazole%cyclosporine%drug interactions
目的:分享肾移植术后患者抗感染治疗期间环孢素剂量调整的经验.方法:通过1例实际病例,并结合文献复习,总结肾移植术后使用阿奇霉素、伏立康唑抗感染治疗期间环孢素血药浓度监测与剂量调整的经验.结果:肾移植术后抗感染治疗时,大环内酯类药物如果无法代替,选用阿奇霉素可能是恰当的选择,必要时需要通过环孢素血药浓度监测来调整药物剂量;伏立康唑与环孢素的相互作用明确,两药联用时,必须通过环孢素血药浓度监测来调整其剂量.结论:肾移植术后,患者使用环孢素治疗期间,临床药师应该从与其有相互作用的药物中选择影响相对较小的药物;在药物剂量调整时,应该在抗感染药物和环孢素之间确定调整的目标药物,从而给临床医师提供合理建议.
目的:分享腎移植術後患者抗感染治療期間環孢素劑量調整的經驗.方法:通過1例實際病例,併結閤文獻複習,總結腎移植術後使用阿奇黴素、伏立康唑抗感染治療期間環孢素血藥濃度鑑測與劑量調整的經驗.結果:腎移植術後抗感染治療時,大環內酯類藥物如果無法代替,選用阿奇黴素可能是恰噹的選擇,必要時需要通過環孢素血藥濃度鑑測來調整藥物劑量;伏立康唑與環孢素的相互作用明確,兩藥聯用時,必鬚通過環孢素血藥濃度鑑測來調整其劑量.結論:腎移植術後,患者使用環孢素治療期間,臨床藥師應該從與其有相互作用的藥物中選擇影響相對較小的藥物;在藥物劑量調整時,應該在抗感染藥物和環孢素之間確定調整的目標藥物,從而給臨床醫師提供閤理建議.
목적:분향신이식술후환자항감염치료기간배포소제량조정적경험.방법:통과1례실제병례,병결합문헌복습,총결신이식술후사용아기매소、복립강서항감염치료기간배포소혈약농도감측여제량조정적경험.결과:신이식술후항감염치료시,대배내지류약물여과무법대체,선용아기매소가능시흡당적선택,필요시수요통과배포소혈약농도감측래조정약물제량;복립강서여배포소적상호작용명학,량약련용시,필수통과배포소혈약농도감측래조정기제량.결론:신이식술후,환자사용배포소치료기간,림상약사응해종여기유상호작용적약물중선택영향상대교소적약물;재약물제량조정시,응해재항감염약물화배포소지간학정조정적목표약물,종이급림상의사제공합리건의.
Objective:To share the experience of cyclosporine dose adjustment during anti-infection treatment after receiving renal transplantation.Methods: Via providing one actual case and literature review, the experience of cyclosporine blood concentration monitoring and dose adjustments was summerized especially for renal transplantation patients receiving anti-infective therapy of azithromycin and voriconazole.Results: During anti-infective therapy in renal transplant recipients, if macrolides can't be replaced,azithromycin might be the appropriate choice, and if necessary, adjust the dose based on cyclosporine blood concentration monitoring. Interactions between voriconazole and cyclosporine are clear, and the dose must be adjusted based on cyclosporine blood concentration monitoring if two drugs are administered simultaneously.Conclusion: After renal transplantation, clinical pharmacists should choose the drug with relatively less possibility of interacting with other drugs for patients being treated with cyclosporine. As for dose adjustment, clinical pharmacists should balance the anti-infection drugs and cyclosporine, and decide the drug to be adjusted in order to provide proper advices to clinicians.