CAJ | 학술논문

目的：探讨根治切除术联合抗病毒治疗肝癌合并乙肝病毒（ HBV ）感染的临床效果。方法：选取2010年4月-2013年4月100例肝癌合并乙肝病毒感染患者为研究对象，按照HBV-DNA水平不同分成高病毒复制组和低病毒复制组（以HBV-DNA载量为105拷贝/ml为标准），比较四组在肝功能、HBV-DNA水平、生存时间、肿瘤复发率和住院时间、住院费用方面的差异性。结果：抗病毒治疗后无论在高病毒复制组和低病毒复制组中，肝功能明显好转，HBV-DNA水平明显低于未抗病毒治疗，且在住院时间、费用、生存时间和肿瘤复发率上抗病毒治疗均好于未抗病毒者，但低病毒复制者在住院时间、住院费用上优于高病毒复制者。在生存时间上高病毒复制者1~2年生存率更好，在肿瘤复发率上低病毒复制者更低。结论：抗病毒结合根治切除术能改善肝癌合并HBV感染者的肝功能和病毒指标，缩短住院时间，延长生存时间。
목적：탐토근치절제술연합항병독치료간암합병을간병독（ HBV ）감염적림상효과。방법：선취2010년4월-2013년4월100례간암합병을간병독감염환자위연구대상，안조HBV-DNA수평불동분성고병독복제조화저병독복제조（이HBV-DNA재량위105고패/ml위표준），비교사조재간공능、HBV-DNA수평、생존시간、종류복발솔화주원시간、주원비용방면적차이성。결과：항병독치료후무론재고병독복제조화저병독복제조중，간공능명현호전，HBV-DNA수평명현저우미항병독치료，차재주원시간、비용、생존시간화종류복발솔상항병독치료균호우미항병독자，단저병독복제자재주원시간、주원비용상우우고병독복제자。재생존시간상고병독복제자1~2년생존솔경호，재종류복발솔상저병독복제자경저。결론：항병독결합근치절제술능개선간암합병HBV감염자적간공능화병독지표，축단주원시간，연장생존시간。
Objective:To investigate the effect of radical resection of hepatocellular carcinoma with combined anti-viral treatment of hepatitis B virus( HBV)infection. Methods:All 100 cases of hepatocellular carcinoma with hepati-tis B virus infection were selected and divided into groups of high and low viral replication of viral replication group ( in HBV-DNA load was 105 copies/ml as standard),again divided into groups with and without anti-virus treat-ment group. Results:The anti - viral therapy with high viral replication in both groups,and low viral replication group,significant improvement in liver function and HBV-DNA levels were significantly lower than those without an-tiretroviral therapy. In the length of hospital stay,cost expense and complications survival time antiviral treatment on tumor recurrence rate were better than those who were not anti-virus,but low viral replication were in complications and length of stay,hospital costs than those on high viral replication. Conclusion:The combination of antiviral radical resection can improve liver HBV infection in patients with liver function and viral indicators,shorter hospital stay.