现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
17期
2452-2455
,共4页
肝脏疾病%原发性肝癌%高尔基蛋白73%肿瘤标记物%临床应用
肝髒疾病%原髮性肝癌%高爾基蛋白73%腫瘤標記物%臨床應用
간장질병%원발성간암%고이기단백73%종류표기물%림상응용
liver disease%primary hepatic carcinoma%Golgi protein 73%tumor marker%clinical application
目的：评价高尔基蛋白73（Golgi protein 73，GP73）作为肝脏疾病尤其是原发性肝癌（primary hepatic carcinoma，PHC）血清学标志物的临床应用价值。方法：分别采用酶联免疫吸附试验和化学发光法定量检测肝占位患者的血清GP73及甲胎蛋白（ AFP）的水平以确定肝占位性质。同时选取PHC患者组、肝硬化患者组及健康体检组作为对照进行GP73水平测定。对PHC患者，进一步分析血清GP73水平与临床病理参数之间的关系。结果：肝占位组GP73的灵敏性及特异性分别为77.27％和85.71％，P<0.05。PHC组、肝硬化组及健康体检组GP73数据比较：PHC组患者GP73值明显高于其余两组，P<0.05。肝硬化组GP73血清含量高于健康体检组，P<0.05。PHC组各数据分组比较分析：GP73血清含量与性别、年龄、肿瘤数目无明显相关性，而与肿瘤直径、肿瘤转移情况、Child分级及肝炎感染情况具有相关性。结论：作为新型血清标志物，GP73与AFP一样，临床检测效果良好，与AFP临床诊断上具有互补性，可用于临床肝占位性质的判定、PHC的诊断，并且对于PHC病情分析、恶性程度判断乃至预后评估等均具有重要临床价值。
目的：評價高爾基蛋白73（Golgi protein 73，GP73）作為肝髒疾病尤其是原髮性肝癌（primary hepatic carcinoma，PHC）血清學標誌物的臨床應用價值。方法：分彆採用酶聯免疫吸附試驗和化學髮光法定量檢測肝佔位患者的血清GP73及甲胎蛋白（ AFP）的水平以確定肝佔位性質。同時選取PHC患者組、肝硬化患者組及健康體檢組作為對照進行GP73水平測定。對PHC患者，進一步分析血清GP73水平與臨床病理參數之間的關繫。結果：肝佔位組GP73的靈敏性及特異性分彆為77.27％和85.71％，P<0.05。PHC組、肝硬化組及健康體檢組GP73數據比較：PHC組患者GP73值明顯高于其餘兩組，P<0.05。肝硬化組GP73血清含量高于健康體檢組，P<0.05。PHC組各數據分組比較分析：GP73血清含量與性彆、年齡、腫瘤數目無明顯相關性，而與腫瘤直徑、腫瘤轉移情況、Child分級及肝炎感染情況具有相關性。結論：作為新型血清標誌物，GP73與AFP一樣，臨床檢測效果良好，與AFP臨床診斷上具有互補性，可用于臨床肝佔位性質的判定、PHC的診斷，併且對于PHC病情分析、噁性程度判斷迺至預後評估等均具有重要臨床價值。
목적：평개고이기단백73（Golgi protein 73，GP73）작위간장질병우기시원발성간암（primary hepatic carcinoma，PHC）혈청학표지물적림상응용개치。방법：분별채용매련면역흡부시험화화학발광법정량검측간점위환자적혈청GP73급갑태단백（ AFP）적수평이학정간점위성질。동시선취PHC환자조、간경화환자조급건강체검조작위대조진행GP73수평측정。대PHC환자，진일보분석혈청GP73수평여림상병리삼수지간적관계。결과：간점위조GP73적령민성급특이성분별위77.27％화85.71％，P<0.05。PHC조、간경화조급건강체검조GP73수거비교：PHC조환자GP73치명현고우기여량조，P<0.05。간경화조GP73혈청함량고우건강체검조，P<0.05。PHC조각수거분조비교분석：GP73혈청함량여성별、년령、종류수목무명현상관성，이여종류직경、종류전이정황、Child분급급간염감염정황구유상관성。결론：작위신형혈청표지물，GP73여AFP일양，림상검측효과량호，여AFP림상진단상구유호보성，가용우림상간점위성질적판정、PHC적진단，병차대우PHC병정분석、악성정도판단내지예후평고등균구유중요림상개치。
Objective:To evaluate the clinical value of serum Golgi protein 73( GP73 )as liver disease expecial the primary hepatic carcinoma( PHC ). Methods:Quantitative detection of serum GP73 and alpha - fetoprotein ( AFP)levels in patients with hepatic space-occupying lesions by using enzyme-linked immunosorbent assay andchemiluminescence method,furthermore,patients with PHC cirrhosis of liver as a control and healthy examination peo-ple as another terms. To patients with PHC,the relationship between serum GP73 levels and the clinical pathologic pa-rameters was analyzed. Results:The sensitivities,positive predictive values of GP73 lever in patients with hepatic space-occupying lesions were 77. 27% and 85. 71%,P<0. 05. Compared with patients with PHC cirrhosis of liver as a control and healthy examination people the lever of GP73. The serum level of GP73 in patients with PHC was sig-nificantly higher than that in patients with cirrhosis and healthy controls,P<0. 05. The serum level of GP73 in pa-tients with cirrhosis was higher than healthy controls,P<0. 05. There was no relationship between serum GP73 and age,gender and tumer amount in patients with PHC. There was some relationship between serum GP73 and tumer size tansfer Child stage and infection. Conclusion:As a new serum marker,GP73 can be used for diagnosis of PHC. More-over,it has important clinical value in analyzing pathogenetic condition,judging malignant degree and prognosis for PHC.
