CAJ | 학술논문

目的:分析别嘌醇不良反应特点和相关因素,为规避临床用药风险提供参考.方法:对北京地区医疗机构近10年报告的107例别嘌醇的不良反应发生特点、规律和预后进行归纳、分析.结果:107例不良反应中严重不良反应27例(占25.23%),最常见的不良反应为皮肤-黏膜系统反应,共70例(占65.42%),其主要表现为皮疹、多形红斑、剥脱性皮炎等,其他不良反应包括肝肾功能异常及胃肠道反应等.结论:临床上使用该药要加强不良反应监测,尤其应注意日总剂量不要大于600 mg.
목적:분석별표순불량반응특점화상관인소,위규피림상용약풍험제공삼고.방법:대북경지구의료궤구근10년보고적107례별표순적불량반응발생특점、규률화예후진행귀납、분석.결과:107례불량반응중엄중불량반응27례(점25.23%),최상견적불량반응위피부-점막계통반응,공70례(점65.42%),기주요표현위피진、다형홍반、박탈성피염등,기타불량반응포괄간신공능이상급위장도반응등.결론:림상상사용해약요가강불량반응감측,우기응주의일총제량불요대우600 mg.
Objective:To analyze characters and associated adverse drug reactions (ADR) of Allopurinol, and to provide reference for preventing the medication risk ofAllopurinol.Methods:Characters, patterns and prognosis of 107 cases ADR induced by Allopurinol in medical institutions of beijing in recent were summarized and analyzed.Results:27 cases of serious ADR happened(25.23%), the most common ADR was happened in skin mucous membrane system, a total number was 70cases (65.42%), its main manifestation were rashes, multiform erythema, exfoliative dermatitis, Other ADR include liver and kidney dysfunction and gastrointestinal reaction. Conclusion:ADR should be monitored whenallopurinol is used in clinic, and especially daily dosage should not be more than 600 mg.