CAJ | 학술논문

目的：采用动态血糖监测系统（CGM ）观察服用拜糖平餐后血糖控制不佳的T2DM 患者联合服用西格列汀治疗后血糖波动情况。方法选择服用拜糖平150 m g／d 3个月，且餐后血糖控制不佳的新诊断T2DM患者35例，联合服用西格列汀100 mg／d 6个月，采用CGM观察血糖控制情况。结果联合服用西格列汀治疗后平均血糖水平[（8.77±1.68）vs（7.32±1.25） mmol／L]、平均血糖水平标准差[（1.73±0.37）vs（1.23±0.25） mmol／L]、平均血糖波动幅度（MAGE）[（4.21±0.94）vs（2.85±0.73） mmol／L]，胰岛素曲线下面积（AUC）AUCIns0～180[（47.4±11.6）vs（40.9±10.7）]均降低，AUCGLP‐10～180[（15.7±4.5）vs （23.8±5.7）]升高。结论联合服用拜糖平和西格列汀可降低血糖波动幅度，改善餐后胰岛素分泌时相，减少餐后胰岛素分泌量。
목적：채용동태혈당감측계통（CGM ）관찰복용배당평찬후혈당공제불가적T2DM 환자연합복용서격렬정치료후혈당파동정황。방법선택복용배당평150 m g／d 3개월，차찬후혈당공제불가적신진단T2DM환자35례，연합복용서격렬정100 mg／d 6개월，채용CGM관찰혈당공제정황。결과연합복용서격렬정치료후평균혈당수평[（8.77±1.68）vs（7.32±1.25） mmol／L]、평균혈당수평표준차[（1.73±0.37）vs（1.23±0.25） mmol／L]、평균혈당파동폭도（MAGE）[（4.21±0.94）vs（2.85±0.73） mmol／L]，이도소곡선하면적（AUC）AUCIns0～180[（47.4±11.6）vs（40.9±10.7）]균강저，AUCGLP‐10～180[（15.7±4.5）vs （23.8±5.7）]승고。결론연합복용배당평화서격렬정가강저혈당파동폭도，개선찬후이도소분비시상，감소찬후이도소분비량。
Objective To observe the effect of additional Sitagliptin treatment on blood glucose fluctuation in type 2 diabetic patients with unsatisfactory blood glucose control under treatment of Acarbose by continuous glucose monitoring (CGM). Methods A total of 35 patients with unsatisfactory blood glucose control under treatment of Acarbose 150 mg/d were enrolled in this study. Sitagliptin 100 mg/d was added to all the subjects ,and follow up for 6 months. CGM was used for the blood glucose monitoring. Results After Sitagliptin treatment ,The mean blood glucose level [(8.77 ± 1.68)vs(7.32 ± 1.25) mmol/L] ,the standard deviation of the mean blood glucose levels for the 24‐hour period [(1.73 ± 0.37)vs(1.23 ± 0.25) mmol/L] ,mean amplitude of glycemic excursions (MAGE) [(4.21 ± 0.94)vs(2.85 ± 0.73) mmol/L] ,AUCIns 0~180 values [(47.4 ± 11.6)vs(40.9 ± 10.7)] were all decreased. AUCGLP‐1 0~180 [(15.7 ± 4.5)vs (23.8 ± 5.7)] was increased. Conclusions The combined administration of both Sitagliptin and Acarbose could decrease blood glucose fluctuations ,improve post prandial insulin secretion phase and decrease post prandial insulin level.