中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2015年
8期
711-713
,共3页
王颖%朱铁虹%佟俊旺%陈冬%魏剑芬%吴乃君%盛佳曦%戚晓渊%毕西娟
王穎%硃鐵虹%佟俊旺%陳鼕%魏劍芬%吳迺君%盛佳晞%慼曉淵%畢西娟
왕영%주철홍%동준왕%진동%위검분%오내군%성가희%척효연%필서연
糖尿病慢性肾脏疾病%糖化血红蛋白%瘦素%血脂
糖尿病慢性腎髒疾病%糖化血紅蛋白%瘦素%血脂
당뇨병만성신장질병%당화혈홍단백%수소%혈지
Chronic kidney disease(CKD) in diabetes%Leptin%Serum lipid
目的：探讨糖尿病慢性肾脏疾病（CKD）患者血清瘦素（Lep）和血脂水平的变化及其临床意义。方法根据UAER水平将120例T2DM患者分为＜30 mg／24 h组41例、30～299 mg／24 h组44例和≥300 mg／24 h组35例，另选取健康志愿者40名作为对照（NC）组。检测FPG、HbA1c、Lep及血脂各项。结果 CKD各组FPG、HbA1c、Lep、TG、TC、LDL‐C水平均高于NC组，HDL‐C低于NC组（P＜0.05）。30～299 mg／24 h组和≥300 mg／24 h组FPG、HbA1c、Lep、TC、TG、LDL‐C水平高于＜30 mg／24 h组，HDL‐C低于＜30 mg／24 h组，且≥300 mg／24 h组高于30～299 mg／24 h组（P＜0.05）。Lep水平与UAER呈正相关（P＜0.01）。结论 CKD患者HbA1 c、Lep、血脂水平均升高，且与微血管病变程度有关，提示 HbA1 c、Lep、血脂水平可预测CKD的进展。
目的：探討糖尿病慢性腎髒疾病（CKD）患者血清瘦素（Lep）和血脂水平的變化及其臨床意義。方法根據UAER水平將120例T2DM患者分為＜30 mg／24 h組41例、30～299 mg／24 h組44例和≥300 mg／24 h組35例，另選取健康誌願者40名作為對照（NC）組。檢測FPG、HbA1c、Lep及血脂各項。結果 CKD各組FPG、HbA1c、Lep、TG、TC、LDL‐C水平均高于NC組，HDL‐C低于NC組（P＜0.05）。30～299 mg／24 h組和≥300 mg／24 h組FPG、HbA1c、Lep、TC、TG、LDL‐C水平高于＜30 mg／24 h組，HDL‐C低于＜30 mg／24 h組，且≥300 mg／24 h組高于30～299 mg／24 h組（P＜0.05）。Lep水平與UAER呈正相關（P＜0.01）。結論 CKD患者HbA1 c、Lep、血脂水平均升高，且與微血管病變程度有關，提示 HbA1 c、Lep、血脂水平可預測CKD的進展。
목적：탐토당뇨병만성신장질병（CKD）환자혈청수소（Lep）화혈지수평적변화급기림상의의。방법근거UAER수평장120례T2DM환자분위＜30 mg／24 h조41례、30～299 mg／24 h조44례화≥300 mg／24 h조35례，령선취건강지원자40명작위대조（NC）조。검측FPG、HbA1c、Lep급혈지각항。결과 CKD각조FPG、HbA1c、Lep、TG、TC、LDL‐C수평균고우NC조，HDL‐C저우NC조（P＜0.05）。30～299 mg／24 h조화≥300 mg／24 h조FPG、HbA1c、Lep、TC、TG、LDL‐C수평고우＜30 mg／24 h조，HDL‐C저우＜30 mg／24 h조，차≥300 mg／24 h조고우30～299 mg／24 h조（P＜0.05）。Lep수평여UAER정정상관（P＜0.01）。결론 CKD환자HbA1 c、Lep、혈지수평균승고，차여미혈관병변정도유관，제시 HbA1 c、Lep、혈지수평가예측CKD적진전。
Objective To explore the changes of serum leptin and lipid levels in type 2 diabetes patients with chronic kidney disease (CKD) and its clinical significance. Methods 120 cases with T2DM were divided into <30 mg/24 h group(n=41) ,30~299 mg/24 h group(n=44) and ≥300 mg/24 h group (n=35) according to the UAER.40 healthy volunteers were selected as normal control (NC) group. FPG , HbA1 c ,serum leptin and lipid were measured. Results In the early stage of diabetic nephropathy group and middle—late stage group ,The levels of FPG ,HbA1 c ,Leptin ,TG ,TC and LDL‐C were higher ,and HDL‐C was lower in different CKD groups than in NC group (P< 0.05).The levels of FPG ,HbA1c , leptin ,TC ,TG LDL‐C were higher ,and HDL‐C was lower in 30~299 mg/24 h group and ≥300 mg/24 h group than in <30 mg/24 h group ,moreover those indexes were higher in ≥300 mg/24 h group than in 30~299 mg/24 h group (P< 0.05). Leptin level was positively correlated with UAER (P< 0.01). Conclusion HbA1 c ,leptin and lipid level is increased in CKD patients ,and correlated with the degrees of microvascular disease. The levels of HbA1 c ,leptin ,blood lipid levels can predict the progress of CKD.
