CAJ | 학술논문

目的：观察晚期非小细胞肺癌化疗的临床疗效以及对凝血4项的影响。方法：选取67例晚期非小细胞肺癌患者作为研究对象，另设健康对照组45例。肺癌组患者采取化疗治疗，对比两组患者的凝血四项指标以及D-二聚体数值。结果：晚期肺癌组患者化疗前凝血酶原时间（ PT）、活化部分凝血活酶时间（ APTT）、凝血酶时间（ TT）、纤维蛋白原（ FIB）、D-二聚体均明显高于健康对照组，P值均<0.05，差异有统计学意义。晚期肺癌组患者化疗后PT显著延长，APTT和TT较治疗前明显缩短，FIB和D-二聚体值均较前明显升高，P值均<0.05，差异有统计学意义。结论：晚期非小细胞肺癌患者普遍存在凝血功能的异常，而化疗往往会加重血液的高凝状态。
목적：관찰만기비소세포폐암화료적림상료효이급대응혈4항적영향。방법：선취67례만기비소세포폐암환자작위연구대상，령설건강대조조45례。폐암조환자채취화료치료，대비량조환자적응혈사항지표이급D-이취체수치。결과：만기폐암조환자화료전응혈매원시간（ PT）、활화부분응혈활매시간（ APTT）、응혈매시간（ TT）、섬유단백원（ FIB）、D-이취체균명현고우건강대조조，P치균<0.05，차이유통계학의의。만기폐암조환자화료후PT현저연장，APTT화TT교치료전명현축단，FIB화D-이취체치균교전명현승고，P치균<0.05，차이유통계학의의。결론：만기비소세포폐암환자보편존재응혈공능적이상，이화료왕왕회가중혈액적고응상태。
Objective:To observe the clinical efficacy of chemotherapy for advanced non-small lung cancer cells as well as the impact on coagulation. Methods:All 67 cases of advanced non-small cell lung cancer patients were research subjects,healthy control group of 45 patients. Cancer patients were treated by chemotherapy. Results:The group of patients with advanced lung cancer before chemotherapy prothrombin time( PT),activated partial thrombo-plastin time( APTT),thrombin time( TT),fibrinogen( FIB),D-dimer were significantly higher than in healthy con-trols group,P<0. 05,the difference was statistically significant. Advanced lung cancer patients after chemotherapy significantly prolonged PT,APTT and TT was significantly shorter than that before treatment,FIB and D-dimer val-ues were significantly higher than before,P<0. 05,the difference was statistically significant. Conclusion:In patients with advanced non-small cell lung cancer treated by chemotherapy are with abnormal coagulation.