中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2015年
8期
829-831
,共3页
普丽芳%苏迎盈%王桂香%白俊
普麗芳%囌迎盈%王桂香%白俊
보려방%소영영%왕계향%백준
美沙酮门诊%艾滋病病毒%丙型肝炎病毒%感染
美沙酮門診%艾滋病病毒%丙型肝炎病毒%感染
미사동문진%애자병병독%병형간염병독%감염
Methadone maintenance treatment%HIV%HCV%Infection
目的 了解开远市美沙酮维持治疗(MMT)在治者HIV/HCV感染率及其危险因素.方法 以2014年6月MMT在治者为研究对象,获得HIV/HCV感染率,采用logistic回归模型分析相关危险因素.结果 2014年6月,开远市MMT在治人数为275人,美沙酮平均治疗时间为(4.0±2.4)年,入组时HIV阳性者142人,感染率为51.6％,美沙酮治疗期间未发现HIV新发感染.入组时HCV阳性者222人,感染率为80.7％,美沙酮治疗期间共发现17例HCV新发感染,新发感染率为32.1％(17/56);HIV/HCV混合感染135人,混合感染率为49.1％.多因素logistic回归分析发现:未婚/离异/丧偶(调整OR=2.39,95％CI:1.29～ 4.43)、有注射毒品史(调整OR=5.52,95％CI:2.69～ 11.35)、有共用注射器史(调整OR=2.32,95％CI:1.04～5.18)及吸毒时间长的MMT者感染HIV的风险更高;对于HCV感染,注射吸毒史为其独立危险因素(调整OR=11.54,95％CI:4.79～27.80).结论 开远市MMT在治者的HIV、HCV、HIV/HCV混合感染率均高于云南省其他地区.应加强注射吸毒人群中清洁针具交换及HIV/HCV干预工作.
目的 瞭解開遠市美沙酮維持治療(MMT)在治者HIV/HCV感染率及其危險因素.方法 以2014年6月MMT在治者為研究對象,穫得HIV/HCV感染率,採用logistic迴歸模型分析相關危險因素.結果 2014年6月,開遠市MMT在治人數為275人,美沙酮平均治療時間為(4.0±2.4)年,入組時HIV暘性者142人,感染率為51.6％,美沙酮治療期間未髮現HIV新髮感染.入組時HCV暘性者222人,感染率為80.7％,美沙酮治療期間共髮現17例HCV新髮感染,新髮感染率為32.1％(17/56);HIV/HCV混閤感染135人,混閤感染率為49.1％.多因素logistic迴歸分析髮現:未婚/離異/喪偶(調整OR=2.39,95％CI:1.29～ 4.43)、有註射毒品史(調整OR=5.52,95％CI:2.69～ 11.35)、有共用註射器史(調整OR=2.32,95％CI:1.04～5.18)及吸毒時間長的MMT者感染HIV的風險更高;對于HCV感染,註射吸毒史為其獨立危險因素(調整OR=11.54,95％CI:4.79～27.80).結論 開遠市MMT在治者的HIV、HCV、HIV/HCV混閤感染率均高于雲南省其他地區.應加彊註射吸毒人群中清潔針具交換及HIV/HCV榦預工作.
목적 료해개원시미사동유지치료(MMT)재치자HIV/HCV감염솔급기위험인소.방법 이2014년6월MMT재치자위연구대상,획득HIV/HCV감염솔,채용logistic회귀모형분석상관위험인소.결과 2014년6월,개원시MMT재치인수위275인,미사동평균치료시간위(4.0±2.4)년,입조시HIV양성자142인,감염솔위51.6％,미사동치료기간미발현HIV신발감염.입조시HCV양성자222인,감염솔위80.7％,미사동치료기간공발현17례HCV신발감염,신발감염솔위32.1％(17/56);HIV/HCV혼합감염135인,혼합감염솔위49.1％.다인소logistic회귀분석발현:미혼/리이/상우(조정OR=2.39,95％CI:1.29～ 4.43)、유주사독품사(조정OR=5.52,95％CI:2.69～ 11.35)、유공용주사기사(조정OR=2.32,95％CI:1.04～5.18)급흡독시간장적MMT자감염HIV적풍험경고;대우HCV감염,주사흡독사위기독립위험인소(조정OR=11.54,95％CI:4.79～27.80).결론 개원시MMT재치자적HIV、HCV、HIV/HCV혼합감염솔균고우운남성기타지구.응가강주사흡독인군중청길침구교환급HIV/HCV간예공작.
Objective To investigate the risk factors for HIV and HCV infections in patients receiving methadone maintenance treatment (MMT) in Kaiyuan,Yunnan province.Methods Patients receiving MMT in June 2014 in Kaiyuan were included in this study.The prevalence of HIV and HCV infections were calculated and logistics regression analysis was conducted to identify related risk factors.Results In June 2014,275 patients received MMT,their average duration of MMT was 4.0 ± 2.4 years.The overall HIV infection rate was 51.6％ (142/275).All the HIV infection occurred before MMT.In 275 patients,222 were infected with HCV before MMT,and 17 new HCV infections occurred during MMT.And the HIV/HCV co-infection rate was 49.1％.The results from multivariate logistic regression analysis indicated that the risk of HIV infection was higher in those who were unmarried/divorced/widowed (adjust OR=2.39,95％CI:1.29-4.43) and injecting drug users (adjust OR=5.52,95％CI:2.69-11.35),sharing needles with others (adjust OR=2.32,95％CI:1.04-5.18) and had longer history of drug use.For HCV infection,injecting drug use was the independence risk factor(adjust OR=11.54,95％CI:4.79-27.80).Conclnsion The prevalence of HIV,HCV infections and HIV/HCV co-infection in patients in MMT clinic were higher in Kaiyuan than in other areas in Yunnan.More intervention should be given to the patients who had history of injecting drug use.
