CAJ | 학술논문

目的了解浙江省台州市2009-2012年新报告成年HIV感染者中合并感染HCV的情况,分析HIV/HCV合并感染者中血浆HCV病毒载量水平.方法对2009-2012年浙江省台州市新报告的572例成年HIV感染者检测HCV抗体,并对HCV抗体阳性的标本进行HCVRNA定量检测.结果共有42例HCV抗体检测阳性,HIV感染者中HCV合并感染率为7.3％(95％CI:5.2％～9.5％).46～ 86岁HIV感染者的HCV合并感染率显著低于18 ～ 45岁年龄组(OR=0.12,95％CI:0.02～0.58);高中及以上文化程度的HIV感染者HCV合并感染率显著低于小学及以下文化程度者(OR=0.13,95％CI:0.02～ 0.78);经血传播HIV感染者HCV合并感染率显著高于异性传播HIV感染者(OR=49.46,95％CI:13.71～ 178.48);同性传播HIV感染者HCV合并感染率则低于异性传播HIV感染者(OR=0.11,95％CI:0.01～ 0.86).42例HIV/HCV合并感染者中33例(78.6％)血浆HCV病毒载量在检测限以上,HCV复制相对活跃,其中HBsAg阳性者血浆HCV RNA检出率(100％)显著高于HBsAg阴性者(75.7％)(P=0.002).9例(21.4％)血浆HCV病毒载量则低于检测下限(5.0×102 IU/ml),处于相对抑制状态.单因素logistic回归分析未发现HIV/HCV合并感染者HCV相对抑制率与其社会人口学特征、HIV传播途径、CD4+T淋巴细胞计数等有关联.结论浙江省台州市HIV感染者中HCV感染率较高,多数HIV/HCV合并感染者血浆HCV病毒载量也较高,其对病情进展影响有待持续观察.
목적 료해절강성태주시2009-2012년신보고성년HIV감염자중합병감염HCV적정황,분석HIV/HCV합병감염자중혈장HCV병독재량수평.방법 대2009-2012년절강성태주시신보고적572례성년HIV감염자검측HCV항체,병대HCV항체양성적표본진행HCVRNA정량검측.결과 공유42례HCV항체검측양성,HIV감염자중HCV합병감염솔위7.3％(95％CI:5.2％～9.5％).46～ 86세HIV감염자적HCV합병감염솔현저저우18 ～ 45세년령조(OR=0.12,95％CI:0.02～0.58);고중급이상문화정도적HIV감염자HCV합병감염솔현저저우소학급이하문화정도자(OR=0.13,95％CI:0.02～ 0.78);경혈전파HIV감염자HCV합병감염솔현저고우이성전파HIV감염자(OR=49.46,95％CI:13.71～ 178.48);동성전파HIV감염자HCV합병감염솔칙저우이성전파HIV감염자(OR=0.11,95％CI:0.01～ 0.86).42례HIV/HCV합병감염자중33례(78.6％)혈장HCV병독재량재검측한이상,HCV복제상대활약,기중HBsAg양성자혈장HCV RNA검출솔(100％)현저고우HBsAg음성자(75.7％)(P=0.002).9례(21.4％)혈장HCV병독재량칙저우검측하한(5.0×102 IU/ml),처우상대억제상태.단인소logistic회귀분석미발현HIV/HCV합병감염자HCV상대억제솔여기사회인구학특정、HIV전파도경、CD4+T림파세포계수등유관련.결론 절강성태주시HIV감염자중HCV감염솔교고,다수HIV/HCV합병감염자혈장HCV병독재량야교고,기대병정진전영향유대지속관찰.
Objective To examine the prevalence and correlates of hepatitis C virus (HCV) co-infection as well as plasma HCV viral load among newly diagnosed HIV-infected adults during 2009-2012 in Taizhou prefecture of Zhejiang province,China.Methods Five hundred and seventy-two adults who were newly diagnosed as HIV-infection were screened for anti-HCV immunoglobulin G (IgG).Plasma HCV RNA was quantified if positive for HCV IgG.Results Forty-two (7.3％) out of the 572 HIV-infected adults were tested positive for HCV IgG.HCV infection was more likely to occur among participants who were infected with HIV through blood transmission (OR=49.46,95％CI:13.71-178.48).Otherwise,HCV infection was less likely to occur among participants who were under 46-86 years of age (OR=0.12,95％CI:0.02-0.58),those with mode of homosexual transmission of HIV (OR=0.11,95％ C I:0.01-0.86),with education of high school or above (OR=0.13,95％ CI:0.02-0.78).Thirty-three (78.6％) of the total 42 HIV-HCV patients with coinfection had detectable plasma HCV RNA,whereas 9 (21.4％) had undetectable plasma HCV RNA (i.e.,lower than 5.0 × 102 IU/ml) or known as relative HCV viral suppression.No significant associations were noticed on factors as:HCV viral suppression and demographics,HIV transmission route and CD4 + T-cell counts according to univariate regression analyses.Conclusion Prevalence of HCV co-infection was relatively high among newly diagnosed HIV-infected adults in this study area.Majority of the HIV-HCV coinfected patients had detectable plasma HCV RNA,of which the long term impact on disease progression deserves called for further research.