CAJ | 학술논문

目的通过Meta分析了解我国儿童青少年MS的流行现状,为早期防治提供科学依据.方法检索2004-2014年在中国期刊全文数据库(CNKI)、万方数据资源系统(Wanfangdata)、维普数据库(VIP)及PubMed中收录的有关中国地区儿童青少年MS患病率研究的文献.根据加强观察性流行病学研究报告规范(STROBE)声明中横断面研究评价标准进行文献质量评价,采用Stata 12.0软件进行数据合并估算患病率,并对性别、体重状态等因素进行亚组分析,采用漏斗图及Egger检验发表偏倚,通过排除其中任意一篇文献对合并效应值的影响进行敏感性分析.结果共纳入19篇文献(5篇英文、14篇中文).依据国际糖尿病联盟(IDF)标准、美国国家胆固醇教育计划成人治疗专家组Ⅲ修订(NCEPⅢ)标准、中国儿童青少年代谢综合征定义和防治建议(CHN2012)标准,我国儿童青少年MS患病率分别为1.8％、2.6％及 2.0％.按IDF标准,男、女童MS患病率分别为2.9％、1.8％,正常、超重、肥胖儿童中MS患病率分别为0.2％、4.7％、17.3％.NCEPⅢ标准、CHN2012标准结果均呈现男生MS患病率高于女生、肥胖组MS患病率＞超重组＞正常组.结论儿童青少年MS呈流行趋势,应用不同诊断标准对MS检出率影响较大.肥胖是MS的重要危险因素,因此应遏制肥胖,对儿童超重、肥胖尽早识别干预,以减少儿童MS的发生.
목적 통과Meta분석료해아국인동청소년MS적류행현상,위조기방치제공과학의거.방법 검색2004-2014년재중국기간전문수거고(CNKI)、만방수거자원계통(Wanfangdata)、유보수거고(VIP)급PubMed중수록적유관중국지구인동청소년MS환병솔연구적문헌.근거가강관찰성류행병학연구보고규범(STROBE)성명중횡단면연구평개표준진행문헌질량평개,채용Stata 12.0연건진행수거합병고산환병솔,병대성별、체중상태등인소진행아조분석,채용루두도급Egger검험발표편의,통과배제기중임의일편문헌대합병효응치적영향진행민감성분석.결과 공납입19편문헌(5편영문、14편중문).의거국제당뇨병련맹(IDF)표준、미국국가담고순교육계화성인치료전가조Ⅲ수정(NCEPⅢ)표준、중국인동청소년대사종합정정의화방치건의(CHN2012)표준,아국인동청소년MS환병솔분별위1.8％、2.6％급 2.0％.안IDF표준,남、녀동MS환병솔분별위2.9％、1.8％,정상、초중、비반인동중MS환병솔분별위0.2％、4.7％、17.3％.NCEPⅢ표준、CHN2012표준결과균정현남생MS환병솔고우녀생、비반조MS환병솔＞초중조＞정상조.결론 인동청소년MS정류행추세,응용불동진단표준대MS검출솔영향교대.비반시MS적중요위험인소,인차응알제비반,대인동초중、비반진조식별간예,이감소인동MS적발생.
Objective To evaluate the prevalence of metabolic syndrome (MS) in Chinese children and adolescents to provide scientific basis for early prevention of MS in the related populations.Methods Studies on CNKI,Wanfangdata,VIP and PubMed databases on related prevalence of metabolic syndrome in Chinese children and adolescents between 2004-2014 were searched.Quality of literatures was evaluated according to the cross-sectional study standard in Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement.Stata 12.0 software was used to estimate the prevalence of MS,as well as on gender,weight and other factors to make subgroup analysis.According to funnel plot and Egger assess publication bias,sensitivity analysis performed by excluding the impact of any article was generated by the combined effect of the value of literature.Results This study included 19 papers from the literature (5 in English,14 in Chinese).According to International Diabetes Federation (IDF),National Cholesterol Education Program Ⅲ (NCEP Ⅲ) and The definition and prevention recommends of metabolic syndrome in Chinese children and adolescents (CHN2012),the prevalence rates of MS in Chinese children were seen as 1.8％,2.6％ and 2.0％.According to IDF,the prevalence rates of MS appeared 2.9％ in boys and 1.8％ in girls,0.2％ in children with normal weight,4.7％ in overweight and 17.3％ in obesity.Both the results from NCEP Ⅲ and CHN2012 showed that the prevalence rates of MS as boys＞girls,obesity＞overweight＞normal weight.Conclusion Prevalence of MS in Chinese children and adolescents showed a general trend.Data under different standards showed different prevalence rates.Obesity appeared an important risk factor of MS,suggesting that in order to control obesity in children,attention should be paid to identifying and carrying out effective interventions on children under overweight or obesity.