CAJ | 학술논문

目的回顾我国空气污染与呼吸系统疾病健康效应的研究,定量分析空气污染物[空气动力学直径＜2.5μm的细颗粒物(PM2.5)和＜10 μm的可吸入颗粒物(PM10)、二氧化硫(SO2)、二氧化氮(NO2)和臭氧(O3)]与人群呼吸系统疾病急性死亡的关系.方法系统收集1989-2014年在PubMed、SpringerLink、Embase、Medline、中国期刊全文数据库、中国生物医学文献数据库和维普中文科技期刊全文数据库公开发表的有关我国空气污染与呼吸系统疾病健康效应的研究文献,总结该类研究在我国各省份的覆盖情况;并依据Meta分析法分别对PM10、PM2.5、NO2、SO2和O3与人群呼吸系统疾病急性死亡关系的定量研究进行分析,采用Stata 12.0软件进行异质性分析后利用固定或随机效应模型合并效应值,并检验发表偏倚.结果共收集到有关空气污染与人群呼吸系统疾病健康效应的研究文献157篇,覆盖我国79.4％的省份.Meta分析结果显不,PM10、PM2.5、NO2、SO2和O3浓度每上升10 μg/m3,人群呼吸系统疾病死亡率分别增加0.50％(95％ CI:0～0.90％)、0.50％ (95％ CI:0.30％～ 0.70％)、1.39％ (95％ CI:0.90％～1.78％)、1.00％(95％CI:0.40％～ 1.59％)和0.10％(95％CI:-1.21％～ 1.39％),各研究均未发现明显发表偏倚.结论我国PM1.、PM2.5、NO2、SO2浓度的上升均会导致人群呼吸系统疾病急性死亡的增加.
목적 회고아국공기오염여호흡계통질병건강효응적연구,정량분석공기오염물[공기동역학직경＜2.5μm적세과립물(PM2.5)화＜10 μm적가흡입과립물(PM10)、이양화류(SO2)、이양화담(NO2)화취양(O3)]여인군호흡계통질병급성사망적관계.방법 계통수집1989-2014년재PubMed、SpringerLink、Embase、Medline、중국기간전문수거고、중국생물의학문헌수거고화유보중문과기기간전문수거고공개발표적유관아국공기오염여호흡계통질병건강효응적연구문헌,총결해류연구재아국각성빈적복개정황;병의거Meta분석법분별대PM10、PM2.5、NO2、SO2화O3여인군호흡계통질병급성사망관계적정량연구진행분석,채용Stata 12.0연건진행이질성분석후이용고정혹수궤효응모형합병효응치,병검험발표편의.결과 공수집도유관공기오염여인군호흡계통질병건강효응적연구문헌157편,복개아국79.4％적성빈.Meta분석결과현불,PM10、PM2.5、NO2、SO2화O3농도매상승10 μg/m3,인군호흡계통질병사망솔분별증가0.50％(95％ CI:0～0.90％)、0.50％ (95％ CI:0.30％～ 0.70％)、1.39％ (95％ CI:0.90％～1.78％)、1.00％(95％CI:0.40％～ 1.59％)화0.10％(95％CI:-1.21％～ 1.39％),각연구균미발현명현발표편의.결론 아국PM1.、PM2.5、NO2、SO2농도적상승균회도치인군호흡계통질병급성사망적증가.
Objective To analyze the associations between air pollution and adverse health outcomes on respiratory diseases and to estimate the short-term effects of air pollutions [Particulate matter with particle size below 10 microns(PM10),PM10 particulate matter with particle size below 2.5 microns (PM2.5),nitrogen dioxide (NO2),sulphur dioxide (SO2) and ozone (O3)] on respiratory mortality in China.Methods Data related to the epidemiological studies on the associations between air pollution and adverse health outcomes of respiratory diseases that published from 1989 through 2014 in China,were collected by systematically searching databases of PubMed,SpringerLink,Embase,Medline,CNKI,CBM and VIP in different provinces of China.Short-term effects between (PM10,PM2.5,NO2,SO2,O3) and respiratory mortality were analyzed by Meta-analysis method,and estimations were pooled by random or fixed effect models,using the Stata 12.0 software.Results A total of 157 papers related to the associations between air pollution and adverse health outcomes of respiratory diseases in China were published,which covered 79.4％ of all the provinces in China.Results from the Meta-analysis showed that a 10 μg/m3 increase in PM10,PM25,NO2,SO2,and O3 was associated with mortality rates as 0.50％ (95％CI:0-0.90％),0.50％ (95％CI:0.30％-0.70％),1.39％ (95％ CI:0.90％-1.78％),1.00％ (95％ CI:0.40％-1.59％) and 0.10％ (95％ CI:-1.21％-1.39％) in respiratory tracts,respectively.No publication bias was found among these studies.Condusion There seemed positive associations existed between PM10/PM2.5/NO2/SO2 and respiratory mortality in China that the relationship called for further attention on air pollution and adverse health outcomes of the respiratory diseases.