CAJ | 학술논문

目的：观察中药熏洗联合还原型谷胱甘肽防治奥沙利铂周围神经毒性的作用。方法：72例随机分为对照组和治疗组，对照组30例在每次奥沙利铂化疗前1h给予还原谷胱甘肽3g静滴0.5h，治疗组42例在对照组疗法基础上，自化疗前1天开始给予温阳活血通络方熏蒸/浸泡四肢，每日1次，连用7天，两组治疗6周期后观察疗效。结果：治疗组的奥沙利铂神经毒性发生率与严重程度情况均明显低于对照组（P＜0.05），结论：温阳活血通络方熏洗联合还原型谷胱甘肽能有效减轻奥沙利铂周围神经毒性。
목적：관찰중약훈세연합환원형곡광감태방치오사리박주위신경독성적작용。방법：72례수궤분위대조조화치료조，대조조30례재매차오사리박화료전1h급여환원곡광감태3g정적0.5h，치료조42례재대조조요법기출상，자화료전1천개시급여온양활혈통락방훈증/침포사지，매일1차，련용7천，량조치료6주기후관찰료효。결과：치료조적오사리박신경독성발생솔여엄중정도정황균명현저우대조조（P＜0.05），결론：온양활혈통락방훈세연합환원형곡광감태능유효감경오사리박주위신경독성。
Objective:To observe the effect of Chinese fumigation and washing therapy combined with glutathione in preventing and treating the neurotoxicity induced by oxaliplatin. Method:72 patients were randomly divided into 2 groups, 30 cases in the control group and 42 cases in the treatment group. The patients in the control group were received of 3g of GSH intravenously in 30 min before chemotherapy with oxaliplatin while the patients in the treatment group were additionally received Chinese fumigation and washing therapy 1 day before chemotherapy with oxaliplatin,once a day for 7 days. The incidence and severity of oxaliplatin-induced neurotoxicity were observed after six weeks of chemotherapy. Result:The neurotoxicity incidence and severity in the treatment group were significantly lower than that in the control group(P<0.05). Conclusion:Chinese fumigation and washing therapycombined with GSH is effective in preventing the neurotoxicity incidenceand reliving the neurotoxicity severity induced by oxaliplatin.