CAJ | 학술논문

雌激素受体（ estrogen receptor，ER）阳性乳腺癌占所有乳腺癌约70％左右，这类乳腺癌被称为管腔型（ Luminal）乳腺癌。与Luminal-A型乳腺癌相比，Luminal-B型乳腺癌ER表达整体水平低，组织学分级高，对内分泌治疗抵抗，预后较差。尽管如此，无论基础还是临床研究，对Luminal-B型乳腺癌的关注度还是不够，仍有很多问题尚未阐明。本文旨在对近年来有关Luminal-B型乳腺癌的基因表达特点和相关分子通路特征等方面进行综述，为后续深入探寻Luminal-B型乳腺癌的病因和治疗策略提供一定的理论基础。
자격소수체（ estrogen receptor，ER）양성유선암점소유유선암약70％좌우，저류유선암피칭위관강형（ Luminal）유선암。여Luminal-A형유선암상비，Luminal-B형유선암ER표체정체수평저，조직학분급고，대내분비치료저항，예후교차。진관여차，무론기출환시림상연구，대Luminal-B형유선암적관주도환시불구，잉유흔다문제상미천명。본문지재대근년래유관Luminal-B형유선암적기인표체특점화상관분자통로특정등방면진행종술，위후속심입탐심Luminal-B형유선암적병인화치료책략제공일정적이론기출。
Estrogen receptor( ER)positive breast cancer accounts for about 70% of all breast cancers and these breast cancers are called luminal breast cancers. Compared with Luminal-A breast cancer,Luminal-B has lower ER expression levels,higher histological grade,and worse prognosis and is resistant for endocrine therapy. However,it has less concerned for Luminal-B breast cancer in clinical or basic study and it has so many unknown points. The aims of this study are to review genetic characters and molecular signaling pathways of Luminal-B breast cancer and to build many basic evidences for clarifying the cause of disease and therapeutic methods of Luminal-B breast cancer.