CAJ | 학술논문

神经母细胞瘤作为儿童最常见的颅外实体肿瘤，超过50％的病例是高危且难治的，长期生存率较低。N-myc及Mdm2-p53通路作为重要的调节因子，其表达水平的异常及功能缺失是其的发生发展及具有不同生物学行为的重要原因。研究神经母细胞瘤相关因子在其发生发展及演变过程中的分子机制对于该病的诊断、评估及治疗均有重要意义。本文就N-myc及Mdm2-p53通路的研究进展及以Mdm2-p53通路为靶向的神经母细胞瘤治疗做一综述。
신경모세포류작위인동최상견적로외실체종류，초과50％적병례시고위차난치적，장기생존솔교저。N-myc급Mdm2-p53통로작위중요적조절인자，기표체수평적이상급공능결실시기적발생발전급구유불동생물학행위적중요원인。연구신경모세포류상관인자재기발생발전급연변과정중적분자궤제대우해병적진단、평고급치료균유중요의의。본문취N-myc급Mdm2-p53통로적연구진전급이Mdm2-p53통로위파향적신경모세포류치료주일종술。
Neuroblastoma( NB)is the most common extracranial malignant tumor of children,over 50 percent of NB cases are still refractory with high risk,and the low event free survival. As important regulators,the abnormal expres-sion level and functional deletion of N-myc and the Mdm2-p53 pathway are necessary for the happening and pro-gression of neuroblastoma. Researching the mechanism of these NB related factors acting on the NB progression have important significance for the diagnosis,assessment and treatment. This review is aimed to summarize the research de-velopment of interaction between N-myc and Mdm2-p53 pathway and the targeted therapy.