CAJ | 학술논문

Vssohibin-1（VASH1）作为新近发现的的蛋白因子，其具有负反馈调节血管生成作用，是由血管内皮生长因子（ vascular endothelial growth factor，VEGF）、成纤维生长因子2（ fibroblast growth factor -2， FGF2）等诱导产生，在多种肿瘤血管生成中扮演着重要的角色，不但可以抑制肿瘤的血管生成，而且对于肿瘤淋巴管生成和淋巴结转移也有强大的抑制作用，提示其有望成为相关肿瘤诊断和治疗的分子标志物以及分子靶向治疗的有效蛋白因子。
Vssohibin-1（VASH1）작위신근발현적적단백인자，기구유부반궤조절혈관생성작용，시유혈관내피생장인자（ vascular endothelial growth factor，VEGF）、성섬유생장인자2（ fibroblast growth factor -2， FGF2）등유도산생，재다충종류혈관생성중분연착중요적각색，불단가이억제종류적혈관생성，이차대우종류림파관생성화림파결전이야유강대적억제작용，제시기유망성위상관종류진단화치료적분자표지물이급분자파향치료적유효단백인자。
Vasohibin-1(VASH1)is induced in response to angiogenesis stimuli such as vascular endothelial factor (VEGF)and fibroblast growth-2(FGF-2),has recently been isolated as a novel negative feedback inhibitor of an-giogenesis. It plays important roles in the development of various tumors ,such as inhibit angiogenesis,tumor lym-phangiogenesis and lymphatic metastasis,it would polentially be a biomarker and a candidate for molecular targeted therapy for patients wirh cancer in the future.