CAJ | 학술논문

乳腺癌干细胞（ breast cancer stem cells，BCSCs）是导致乳腺癌发生、转移、耐药、复发等的重要原因。MicroRNAs（miRNAs）是近年来发现的一种非编码小分子RNA，可通过与靶标基因的3'-非翻译区（3'-UTR）的完全或不完全配对，抑制靶标基因的翻译或降解靶标基因，从而发挥多种生物学功能。miRNAs在BCSCs中的异常表达可调控 BCSCs的自我更新、抗凋亡、上皮间质转化（ epithelial-mesenchymal transition， EMT）等生物学行为，从而促进乳腺癌的复发、转移。以miRNAs为研究靶点，为乳腺癌的诊断、预后及治疗提供了全新的思路。本文就近年来该方面的研究进展简要综述。
유선암간세포（ breast cancer stem cells，BCSCs）시도치유선암발생、전이、내약、복발등적중요원인。MicroRNAs（miRNAs）시근년래발현적일충비편마소분자RNA，가통과여파표기인적3'-비번역구（3'-UTR）적완전혹불완전배대，억제파표기인적번역혹강해파표기인，종이발휘다충생물학공능。miRNAs재BCSCs중적이상표체가조공 BCSCs적자아경신、항조망、상피간질전화（ epithelial-mesenchymal transition， EMT）등생물학행위，종이촉진유선암적복발、전이。이miRNAs위연구파점，위유선암적진단、예후급치료제공료전신적사로。본문취근년래해방면적연구진전간요종술。
Breast cancer stem cells plays significant roles in tumor formation,metastasis,resistance to anticancer therapies and cancer relapse. miRNAs are conserved small non-coding RNAs which can bind to the seed sequence within 3'-UTR of target mRNAs,leading to destabilization or translational suppression of the target mRNAs. There-fore,they control the self-renewal,apopotosis and EMT of BCSCs and lead to the relapse and metastasis of breast cancer. Studies targeting on miRNAs suggest a novel diagnostic and therapeutic strategy for breast carcinoma. This re-view summarizes the recent progression on the research field of miRNAs of BCSCs.