CAJ | 학술논문

目的：观察电子止吐仪联合托烷司琼预防顺铂化疗所致呕吐的疗效。方法：采用随机、自身交叉对照的方法，将120例接受两周期含顺铂联合化疗的患者，随机分为AB组60例、BA组60例。AB组第1周期应用电子止吐仪联合托烷司琼止吐，第2周期单用托烷司琼止吐；BA组第1周期单用托烷司琼止吐，第2周期应用电子止吐仪联合托烷司琼止吐。观察和记录两组患者化疗后恶心、呕吐的控制情况。结果：AB组化疗第1周期（A方案）和第2周期（B方案）恶心的有效控制率分别为93.1％、79.3％，呕吐有效控制率分别为86.2％、70.7％，差异有统计学意义（ P<0.05）；BA组化疗第1周期（ B方案）和第2周期（ A方案）恶心的有效控制率分别为71.7％、93.3％，呕吐有效控制率分别为70.0％、86.7％，差异有统计学意义（ P<0.05）。两种方案的主要不良反应为头痛、眩晕、腹泻、便秘、心悸、口干等，不良反应发生率比较差异无统计学意义（P>0.05）。结论：电子止吐仪联合托烷司琼预防顺铂化疗所致呕吐优于单用托烷司琼，不良反应可以耐受，可作为防治顺铂化疗所致呕吐的常规措施。
목적：관찰전자지토의연합탁완사경예방순박화료소치구토적료효。방법：채용수궤、자신교차대조적방법，장120례접수량주기함순박연합화료적환자，수궤분위AB조60례、BA조60례。AB조제1주기응용전자지토의연합탁완사경지토，제2주기단용탁완사경지토；BA조제1주기단용탁완사경지토，제2주기응용전자지토의연합탁완사경지토。관찰화기록량조환자화료후악심、구토적공제정황。결과：AB조화료제1주기（A방안）화제2주기（B방안）악심적유효공제솔분별위93.1％、79.3％，구토유효공제솔분별위86.2％、70.7％，차이유통계학의의（ P<0.05）；BA조화료제1주기（ B방안）화제2주기（ A방안）악심적유효공제솔분별위71.7％、93.3％，구토유효공제솔분별위70.0％、86.7％，차이유통계학의의（ P<0.05）。량충방안적주요불량반응위두통、현훈、복사、편비、심계、구간등，불량반응발생솔비교차이무통계학의의（P>0.05）。결론：전자지토의연합탁완사경예방순박화료소치구토우우단용탁완사경，불량반응가이내수，가작위방치순박화료소치구토적상규조시。
Objective:To observe clinical efficacy and ADR of electronic antiemetic acupuncture combined with tropisetron in the prevention of vomiting induced by cisplatin chemotherapy. Methods:Randomized self-cross con-trolled method was applied. All 120 patients received two courses of cisplatin based chemotherapy were randomized in-to group AB and BA. Group AB received electronic antiemetic acupuncture combined with tropisetron in the first cycle while tropisetron alone in the second cycle. Group BA was given tropisetron alone in the first cycle while electronic an-tiemetic acupuncture combined with tropisetron in the second cycle. Observe and record two groups patients after chemotherapy control nausea and vomiting. Results:Rate of improvement of nausea for the AB group of the first cycle (A)and the second cycle(B)were 93. 1% vs 79. 3%. Response rate of prevention of vomit for the AB group of the first cycle(A)and the second cycle(B)were 86. 2% vs 70. 7%(P<0. 05). Response rate of improvement of nausea for the BA group of the first cycle(B)and the second cycle(A)were 71. 7% vs 93. 3%. Response rate of prevention of vomit for the BA group of the first cycle(B)and the second cycle(A)were 70. 0% vs 86. 7%(P<0. 05). The most common ADR in both regimens were headache,dizziness,diarrhea,constipation,heart palpitations,mouth dry. There was no statistical significance in the incidence of ADR(P>0. 05). Conclusion:The treatment of electronic an-tiemetic acupuncture in combination with tropisetron on had greater effect in prevention of vomiting induced by cispla-tin chemotherapy,with tolerable toxcity profile. It can be used conventionally in the chemotherapy.