CAJ | 학술논문

目的：评价伽玛刀联合肝动脉栓塞化疗（ TACE ）与单纯TACE治疗肝癌的远期疗效及安全性。方法：计算机检索国内外相关数据库，由两名评价者纳入国内外公开发表的有关伽玛刀联合TACE治疗肝癌与单纯TACE治疗肝癌的临床随机对照试验。采用Meta分析方法，在RevMan5.1软件中统计分析相应指标。结果：纳入8项独立的临床随机对照试验研究共685名患者，Meta分析结果显示：伽玛刀联合TACE组的1、2年生存率与单纯TACE组相比有统计学差异（ P<0.01）。结论：伽玛刀联合TACE治疗肝癌的远期疗效优于单纯TACE治疗。
목적：평개가마도연합간동맥전새화료（ TACE ）여단순TACE치료간암적원기료효급안전성。방법：계산궤검색국내외상관수거고，유량명평개자납입국내외공개발표적유관가마도연합TACE치료간암여단순TACE치료간암적림상수궤대조시험。채용Meta분석방법，재RevMan5.1연건중통계분석상응지표。결과：납입8항독립적림상수궤대조시험연구공685명환자，Meta분석결과현시：가마도연합TACE조적1、2년생존솔여단순TACE조상비유통계학차이（ P<0.01）。결론：가마도연합TACE치료간암적원기료효우우단순TACE치료。
Objective:To estimate the efficacy and safety of body gamma knife( GK)combined with transcatheter arterial chemoembolization( TACE)in comparison with TACE alone in the treatment of primary hepatocellular carci-noma( PHC). Methods:We searched the Cochrance Library,PubMed,Embase,CBM,CNKI,VIP and Wanfang( from 2005 to 2012)for relevant studies. Two reviewers independently retrieved clinical controlled trials according to the in-clusion and exclusion criteria,assessed the methodological quality of included trials,and extracted data. Meta-analy-sis was performed by RevMen 5. 1 software. Results:Eight studies involving 685 patients were included. The results of meta-analysis showed that gamma knife combined with TCAE,compared with TACE alone,could significantly im-proved survival(P<0. 01),while there was no significant difference in side effect(P>0. 05). Conclusion:The effect with body gamma knife plus TACE was better than with TACE alone in the treatment of PHC.