实验与检验医学
實驗與檢驗醫學
실험여검험의학
EXPERIMENTAL AND LABORATORY MEDICINE
2015年
4期
427-429
,共3页
特发性中枢性性早熟%胰岛素样生长因子-1%促黄体生成素
特髮性中樞性性早熟%胰島素樣生長因子-1%促黃體生成素
특발성중추성성조숙%이도소양생장인자-1%촉황체생성소
Idiopathic central precocious puberty%IGF-1%LH
目的：探讨胰岛素样生长因子-1(IGF-1)在儿童性早熟中的诊断价值。方法收集特发性中枢性性早熟(ICPP)组101例、单纯性乳房早发育（SPT)组96例，同时收集青春发育前健康女童85例为对照组。用化学发光法检测ICPP组、SPT组及对照组的IGF-1和LH峰值水平。结果 ICPP组血清IGF-1水平[(361.26±108.55)ng/m1]明显高于SPT组[(232.62±81.14) ng/m1]和对照组[(221.44±88.91)ng/m1]，差异有统计学意义(P<0.05)；SPT 组IGF-1水平与对照组比较，差异无统计学意义(P>0.05)； ICPP组IGF-1水平与LH峰值呈显著正相关(r2=0.6181,P<0.01)；IGF-1>298.58ng/ml对诊断ICPP的灵敏度、特异度、阳性预测值分别为94.6%、96.0%、95.1%。结论 IGF-1水平的测定可作为ICPP诊断的参考指标，对ICPP和SPT有鉴别诊断意义。
目的：探討胰島素樣生長因子-1(IGF-1)在兒童性早熟中的診斷價值。方法收集特髮性中樞性性早熟(ICPP)組101例、單純性乳房早髮育（SPT)組96例，同時收集青春髮育前健康女童85例為對照組。用化學髮光法檢測ICPP組、SPT組及對照組的IGF-1和LH峰值水平。結果 ICPP組血清IGF-1水平[(361.26±108.55)ng/m1]明顯高于SPT組[(232.62±81.14) ng/m1]和對照組[(221.44±88.91)ng/m1]，差異有統計學意義(P<0.05)；SPT 組IGF-1水平與對照組比較，差異無統計學意義(P>0.05)； ICPP組IGF-1水平與LH峰值呈顯著正相關(r2=0.6181,P<0.01)；IGF-1>298.58ng/ml對診斷ICPP的靈敏度、特異度、暘性預測值分彆為94.6%、96.0%、95.1%。結論 IGF-1水平的測定可作為ICPP診斷的參攷指標，對ICPP和SPT有鑒彆診斷意義。
목적：탐토이도소양생장인자-1(IGF-1)재인동성조숙중적진단개치。방법수집특발성중추성성조숙(ICPP)조101례、단순성유방조발육（SPT)조96례，동시수집청춘발육전건강녀동85례위대조조。용화학발광법검측ICPP조、SPT조급대조조적IGF-1화LH봉치수평。결과 ICPP조혈청IGF-1수평[(361.26±108.55)ng/m1]명현고우SPT조[(232.62±81.14) ng/m1]화대조조[(221.44±88.91)ng/m1]，차이유통계학의의(P<0.05)；SPT 조IGF-1수평여대조조비교，차이무통계학의의(P>0.05)； ICPP조IGF-1수평여LH봉치정현저정상관(r2=0.6181,P<0.01)；IGF-1>298.58ng/ml대진단ICPP적령민도、특이도、양성예측치분별위94.6%、96.0%、95.1%。결론 IGF-1수평적측정가작위ICPP진단적삼고지표，대ICPP화SPT유감별진단의의。
Objective To discuss the diagnostic value of the insulin-like growth factor-1 (IGF-1) in children precocious pu-berty. Methods A total of 101 girls with idiopathic central precocious puberty (ICPP), 96 girls with simple premature thelarche (SPT) were collected as case groups, and 85 healthy girls in prepuberty were collected as the control group. The level of IGF-1 and the peak of luteinizing hormone (LH) in the serum of all the enrolled subjects were detected by using Chemiluminescence. Results The level of IGF-1 in ICPP groups were 361.26±108.55ng/ml, obviously higher than that in SPT groups (232.62±81.14ng/ml) and in controls groups (221.44±88.91ng/ml).The difference above was statistically significant (P<0.05), there was no signifi-cantly difference in the levels of IGF-1between SPT group and controls group (P>0.05); the levels of IGF-1 have a remarkable positive correlation with the peak of LH (r2=0.6181,P<0.01);the IGF-1>298.58ng/ml has the degree of sensitivity(94.6%), specific (96.0%) and positive predictive value (95.1%) for the diagnosis of ICPP. Conclusion The serum concentrate of IGF-1 has a value of reference index in the diagnosis of ICPP and a significance in distinguishing between ICPP and SPT.
