CAJ | 학술논문

目的研究代谢综合征(metabolic syndrome,MS)与泌尿系结石复发之间的相关性.方法回顾性分析2008年3月至2012年2月住院治疗的泌尿系结石患者资料,采用2007年中国成人血脂异常防治指南制订联合委员会修订后的MS诊断标准将患者分为MS组和非MS组.随访24～ 72个月,中位时间47个月,分析两组患者结石复发情况的差异.结果共纳入218例泌尿系结石患者,其中52例伴有MS.MS组29例(55.8％)出现泌尿系结石复发,非MS组为66例(39.8％),差异有统计学意义(P =0.042).Kaplan-Meier曲线显示,MS组中位复发间隔为36个月,非MS组为59个月(Log-rank检验,P=0.019).多元Cox回归模型分析结果显示,MS与泌尿系结石复发相关(HR=1.817,95％CI1.105～2.988,P=0.011),而性别(P =0.336)、年龄(P =0.246)及初次就诊时是否为复发性泌尿系结石(P=0.051)与泌尿系结石复发不相关.结论 MS是泌尿系结石复发的独立危险因素.对于合并MS的结石患者,预防结石复发时应重视MS的治疗.
목적 연구대사종합정(metabolic syndrome,MS)여비뇨계결석복발지간적상관성.방법 회고성분석2008년3월지2012년2월주원치료적비뇨계결석환자자료,채용2007년중국성인혈지이상방치지남제정연합위원회수정후적MS진단표준장환자분위MS조화비MS조.수방24～ 72개월,중위시간47개월,분석량조환자결석복발정황적차이.결과 공납입218례비뇨계결석환자,기중52례반유MS.MS조29례(55.8％)출현비뇨계결석복발,비MS조위66례(39.8％),차이유통계학의의(P =0.042).Kaplan-Meier곡선현시,MS조중위복발간격위36개월,비MS조위59개월(Log-rank검험,P=0.019).다원Cox회귀모형분석결과현시,MS여비뇨계결석복발상관(HR=1.817,95％CI1.105～2.988,P=0.011),이성별(P =0.336)、년령(P =0.246)급초차취진시시부위복발성비뇨계결석(P=0.051)여비뇨계결석복발불상관.결론 MS시비뇨계결석복발적독립위험인소.대우합병MS적결석환자,예방결석복발시응중시MS적치료.
Objective To investigate the relationship between metabolic syndrome (MS) and recurrence of urolithiasis.Methods A retrospective analysis was performed in urinary stone patients from March 2008 to February 2012.Patients were divided into MS group and non-MS group according to the diagnose criteria of metabolic syndrome (2007 version) by the joint committee for developing Chinese guidelines on prevention and treatment of dyslipidemia in adults.The patients were followed up for 24-72months (median 47 months) since operation.The difference of stone recurrence was compared between the 2 groups.Results Two hundred and eighteen patients with urinary stone disease were enrolled.Of them,52 patients were diagnosed with MS.Stone recurrence occurred in 29 patients (55.8％) of MS group,whereas 66 patients (39.8％) of non-MS group suffered stone recurrence.It demonstrated the median recurrence free survival of group MS and non-MS was 36 months and 59 months by Kaplan-Meier analysis,respectively (Log-rank test,P =0.019).Multivariate Cox regression analysis results revealed that MS was significantly associated with stone recurrence (HR 1.817,95％ CI 1.105-2.988,P =0.011),however,the gender (P =0.336),age (P =0.246) and recurrence urolithiasis at first visit (P =0.051) were not associated with stone recurrence.Conclusions MS is an independent risk factor for urinary stone recurrence.It is suggested that the treatment of MS may have a important role in prevention of stone recurrence in MS patients with urolithiasis.