中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2015年
8期
704-707
,共4页
韦艳红%刘艳%康晓新%赵宇%尹璐
韋豔紅%劉豔%康曉新%趙宇%尹璐
위염홍%류염%강효신%조우%윤로
氨基末端B型脑钠肽前体%急性冠状动脉综合征%同型半胱氨酸%C反应蛋白
氨基末耑B型腦鈉肽前體%急性冠狀動脈綜閤徵%同型半胱氨痠%C反應蛋白
안기말단B형뇌납태전체%급성관상동맥종합정%동형반광안산%C반응단백
Amino terminal B-type natriuretic peptide precursor%Acute coronary syndrome%Homocysteine%C-reactive protein
目的 探讨血浆氨基末端B型脑钠肽前体(NT-proBNP)水平与老年急性冠状动脉综合征(ACS)患者危险因素的相关性.方法 将128例ACS患者根据病情分为不稳定型心绞痛(UAP)组52例,ST段抬高型心肌梗死(STEMI)组35例,非ST段抬高型心肌梗死(NSTEMI)组41例,并选取健康老年人45名作为健康对照组.记录受试者血压、体质量指数(BMI)、每日吸烟数等一般资料.抽取静脉血进行血浆NT-proBNP、心肌肌钙蛋白I(cTnI)、同型半胱氨酸(Hcy)、血脂、C反应蛋白(CRP)等实验室检查.通过超声心动图测量左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)和左心室射血分数(LVEF),并比较NT-proBNP与其他指标的相关性.结果 UAP组、STEMI组、NSTEMI组患者NT-proBNP水平均显著高于健康对照组[(794.18± 182.64)、(872.43± 245.67)、(557.25±163.81) ng/L与(125.84±59.27) ng/L,P均＜0.05];ACS患者血浆NT-proBNP与收缩压、舒张压、Hcy和CRP水平呈正相关(r值分别为0.182、0.176、0.281、0.191,P值分别为0.040、0.043、0.001、0.031);与LVEF水平呈负相关(r=-0.247,P=0.005).结论 血浆NT-proBNP是监测ACS病情的敏感指标,其与Hcy、CRP、cTnI联合检测对诊断和治疗ACS具有指导意义.
目的 探討血漿氨基末耑B型腦鈉肽前體(NT-proBNP)水平與老年急性冠狀動脈綜閤徵(ACS)患者危險因素的相關性.方法 將128例ACS患者根據病情分為不穩定型心絞痛(UAP)組52例,ST段抬高型心肌梗死(STEMI)組35例,非ST段抬高型心肌梗死(NSTEMI)組41例,併選取健康老年人45名作為健康對照組.記錄受試者血壓、體質量指數(BMI)、每日吸煙數等一般資料.抽取靜脈血進行血漿NT-proBNP、心肌肌鈣蛋白I(cTnI)、同型半胱氨痠(Hcy)、血脂、C反應蛋白(CRP)等實驗室檢查.通過超聲心動圖測量左心室舒張末期內徑(LVEDD)、左心室收縮末期內徑(LVESD)和左心室射血分數(LVEF),併比較NT-proBNP與其他指標的相關性.結果 UAP組、STEMI組、NSTEMI組患者NT-proBNP水平均顯著高于健康對照組[(794.18± 182.64)、(872.43± 245.67)、(557.25±163.81) ng/L與(125.84±59.27) ng/L,P均＜0.05];ACS患者血漿NT-proBNP與收縮壓、舒張壓、Hcy和CRP水平呈正相關(r值分彆為0.182、0.176、0.281、0.191,P值分彆為0.040、0.043、0.001、0.031);與LVEF水平呈負相關(r=-0.247,P=0.005).結論 血漿NT-proBNP是鑑測ACS病情的敏感指標,其與Hcy、CRP、cTnI聯閤檢測對診斷和治療ACS具有指導意義.
목적 탐토혈장안기말단B형뇌납태전체(NT-proBNP)수평여노년급성관상동맥종합정(ACS)환자위험인소적상관성.방법 장128례ACS환자근거병정분위불은정형심교통(UAP)조52례,ST단태고형심기경사(STEMI)조35례,비ST단태고형심기경사(NSTEMI)조41례,병선취건강노년인45명작위건강대조조.기록수시자혈압、체질량지수(BMI)、매일흡연수등일반자료.추취정맥혈진행혈장NT-proBNP、심기기개단백I(cTnI)、동형반광안산(Hcy)、혈지、C반응단백(CRP)등실험실검사.통과초성심동도측량좌심실서장말기내경(LVEDD)、좌심실수축말기내경(LVESD)화좌심실사혈분수(LVEF),병비교NT-proBNP여기타지표적상관성.결과 UAP조、STEMI조、NSTEMI조환자NT-proBNP수평균현저고우건강대조조[(794.18± 182.64)、(872.43± 245.67)、(557.25±163.81) ng/L여(125.84±59.27) ng/L,P균＜0.05];ACS환자혈장NT-proBNP여수축압、서장압、Hcy화CRP수평정정상관(r치분별위0.182、0.176、0.281、0.191,P치분별위0.040、0.043、0.001、0.031);여LVEF수평정부상관(r=-0.247,P=0.005).결론 혈장NT-proBNP시감측ACS병정적민감지표,기여Hcy、CRP、cTnI연합검측대진단화치료ACS구유지도의의.
Objective To study the correlation between amino terminal B-type natriuretic peptide precursor(NT-proBNP) and risk factors of acute coronary syndrome (ACS) with elder patients.Methods One hundred and twenty-eight ACS patients were divided into unstable angina pectoris (UAP) group with 52 samples,ST elevation myocardial infarction (STEMI) group with 35 samples and non-ST elevation myocardial infarction (NSTEMI) group with 41 samples.Meanwhile 45 healthy elder people were adopted as control group.Firstly,the subjects of blood pressure,body mass index (BMI) and smoking numbers were measured.Secondly,venous blood was collected to assay NT-proBNP,cardiac troponin Ⅰ (cTn Ⅰ),homocysteine (Hcy),blood-lipoids and C-reactive protein(CRP).Lastly,ultrasonic cardiogram was used to test left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter (LVESD) and left ventricular ejection fraction (LVEF).In addition,correlation analysis was researched between NT-proBNP and other factors.Results NT-proBNP levels of UAP,STEMI and NSTEMI groups were significantly higher than the control group ((794.18±182.64) ng/L,(872.43±245.67) ng/L,(557.25±163.81) ng/L) and (125.84±59.27) ng/L,P ＜ 0.05).NT-proBNP was positive correlation with systolic blood pressure,diastolic blood pressure,Hcy and CRP (r=0.182,0.176,0.281,0.191;P=0.040,0.043,0.001,0.031),however negative with LVEF(r=-0.247,P =0.005).Conclusion NT-proBNP level is sensitive to monitor ACS variety,and it is significant to test NT-proBNP combining Hcy,CRP,and cTn Ⅰ for diagnosing and treating ACS.
