中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
25期
19-20
,共2页
高血压%口服葡萄糖耐量试验%高胰岛素血症%胰岛素抵抗
高血壓%口服葡萄糖耐量試驗%高胰島素血癥%胰島素牴抗
고혈압%구복포도당내량시험%고이도소혈증%이도소저항
Hypertension%Oral glucose tolerance test%Hyperinsulinemia%Insulin resistance
目的：探讨高血压与胰岛素抵抗的关系。方法1133例做口服葡萄糖耐量试验(OGTT)的研究对象，排除360例不符合标准的患者后，剩余773例分为高血压(93例)与非高血压(680例)两组，再分别把体质量指数(BMI)<24 kg/m2视分为正常体重组，把BMI≥24 kg/m2定为肥胖组；OGTT试验中，检测各时相的血糖、胰岛素、C肽数值并进行统计分析。结果BMI≥24 kg/m2的高血压或非高血压者，其血糖、胰岛素、C肽均值分别高于BMI<24 kg/m2者(P<0.05)。BMI<24 kg/m2的高血压与非高血压者对比，糖负荷后1.0 h高血压患者血糖显著高于非高血压者(P>0.05)。BMI≥24 kg/m2的高血压患者，除3.0 h血糖外，其余时相血糖、胰岛素、C肽与非高血压组比较，差异有统计学意义(P<0.05)。结论肥胖合并高血压患者有明显的“三高”，即高血糖、高胰岛素、高C肽血症。
目的：探討高血壓與胰島素牴抗的關繫。方法1133例做口服葡萄糖耐量試驗(OGTT)的研究對象，排除360例不符閤標準的患者後，剩餘773例分為高血壓(93例)與非高血壓(680例)兩組，再分彆把體質量指數(BMI)<24 kg/m2視分為正常體重組，把BMI≥24 kg/m2定為肥胖組；OGTT試驗中，檢測各時相的血糖、胰島素、C肽數值併進行統計分析。結果BMI≥24 kg/m2的高血壓或非高血壓者，其血糖、胰島素、C肽均值分彆高于BMI<24 kg/m2者(P<0.05)。BMI<24 kg/m2的高血壓與非高血壓者對比，糖負荷後1.0 h高血壓患者血糖顯著高于非高血壓者(P>0.05)。BMI≥24 kg/m2的高血壓患者，除3.0 h血糖外，其餘時相血糖、胰島素、C肽與非高血壓組比較，差異有統計學意義(P<0.05)。結論肥胖閤併高血壓患者有明顯的“三高”，即高血糖、高胰島素、高C肽血癥。
목적：탐토고혈압여이도소저항적관계。방법1133례주구복포도당내량시험(OGTT)적연구대상，배제360례불부합표준적환자후，잉여773례분위고혈압(93례)여비고혈압(680례)량조，재분별파체질량지수(BMI)<24 kg/m2시분위정상체중조，파BMI≥24 kg/m2정위비반조；OGTT시험중，검측각시상적혈당、이도소、C태수치병진행통계분석。결과BMI≥24 kg/m2적고혈압혹비고혈압자，기혈당、이도소、C태균치분별고우BMI<24 kg/m2자(P<0.05)。BMI<24 kg/m2적고혈압여비고혈압자대비，당부하후1.0 h고혈압환자혈당현저고우비고혈압자(P>0.05)。BMI≥24 kg/m2적고혈압환자，제3.0 h혈당외，기여시상혈당、이도소、C태여비고혈압조비교，차이유통계학의의(P<0.05)。결론비반합병고혈압환자유명현적“삼고”，즉고혈당、고이도소、고C태혈증。
Objective To investigate relationship between hypertension and insulin resistance. Methods There were 1133 patients receiving oral glucose tolerance test (OGTT) as study subjects, and 360 unqualified cases among them were eliminated. The other 773 cases were divided into hypertension group (93 cases) and non-hypertension group (680 cases). Patients with body mass index (BMI) <24 kg/m2 were taken as normal weight group, and those with BMI ≥24 kg/m2 as obesity group. Detections were made on blood glucose, insulin, and C-peptide in different time points for statistical analysis.Results Patients with BMI≥24 kg/m2 in both hypertension and non-hypertension groups had higher blood glucose, insulin, and C-peptide than those with BMI <24 kg/m2 (P<0.05). Patients with BMI <24 kg/m2 in hypertension group had higher 1.0 h blood glucose after glucose load than those in non-hypertension group (P>0.05). Patients with BMI ≥24 kg/m2 in hypertension group had statistically significant differences of blood glucose, insulin, and C-peptide with non-hypertension group, with exception of 3.0 h blood glucose (P<0.05).Conclusion Obesity complicated with hypertension patients have obvious high levels of blood glucose, insulin, and C-peptide.
