CAJ | 학술논문

目的：：探讨血清视黄醇结合蛋白4(RBP4)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平与冠心病的稳定性、恶化及选择性冠状动脉(冠脉)造影结果的关系。方法：将89例冠心病患者根据冠脉造影结果分为4组,造影结果正常者14例为对照组,异常者根据冠脉病变支数,分为单支病变组22例,2支病变组21例和3支病变组32例。于造影前采集血标本,酶联免疫吸附法分别定量测定4组患者Lp-PLA2、RBP4水平。结果：3支病变组患者血清RBP4和Lp-PLA2水平均明显高于对照组、单支和2支病变组(P<0.01),而2支病变组患者血清Lp-PLA2水平亦均显著高于对照组和单支病变组(P<0.01)；单支病变与对照组Lp-PLA2水平差异无统计学意义(P>0.05),单支和2支病变组及对照组血清RBP4水平差异均无统计学意义(P>0.05)。结论：冠心病患者血清Lp-PLA2、RBP4水平与冠脉病变支数有关,可以在一定程度上反映冠脉的狭窄程度。
목적：：탐토혈청시황순결합단백4(RBP4)、지단백상관린지매A2(Lp-PLA2)수평여관심병적은정성、악화급선택성관상동맥(관맥)조영결과적관계。방법：장89례관심병환자근거관맥조영결과분위4조,조영결과정상자14례위대조조,이상자근거관맥병변지수,분위단지병변조22례,2지병변조21례화3지병변조32례。우조영전채집혈표본,매련면역흡부법분별정량측정4조환자Lp-PLA2、RBP4수평。결과：3지병변조환자혈청RBP4화Lp-PLA2수평균명현고우대조조、단지화2지병변조(P<0.01),이2지병변조환자혈청Lp-PLA2수평역균현저고우대조조화단지병변조(P<0.01)；단지병변여대조조Lp-PLA2수평차이무통계학의의(P>0.05),단지화2지병변조급대조조혈청RBP4수평차이균무통계학의의(P>0.05)。결론：관심병환자혈청Lp-PLA2、RBP4수평여관맥병변지수유관,가이재일정정도상반영관맥적협착정도。
Objective:To investigate the relationships between the levels of retinol binding protein 4 ( RBP4 ) and lipoprotein associated phospholipase A2 ( Lp-PLA2 ) , and stability of deterioration of coronary heart disease and selective coronary angiography results. Methods:Eighty-nine patients with coronary heart disease were divided into the control group( without vessel lesion) ,1 vessel lesion group,2 branches lesion group and 3 branches lesion group according to the results of coronary angiography. The levels of Lp-PLA2 and RBP4 in 4 groups before angiography were detected by enzyme-linked immunosorbent assay. Results:The levels of Lp-PLA2 and RBP4 in 3 branches lesion group were significantly higher than those in control group,1 vessel lesion group and 2 branches lesion group(P<0. 01). The level of Lp-PLA2 in 2 branches lesion group was significantly higher than those in control group and 1 vessel lesion group(P<0. 01). The difference of the Lp-PLA2 levels between 1 branch lesion group and control group was not statistically significant(P>0. 05). The difference of the RBP4 levels between 1 branch lesion group,2 branches lesion group 2 and control group were not statistically significant(P >0. 05). Conclusions:The levels of serum Lp-PLA2 and RBP4 in patients with coronary heart disease are related to the number of coronary artery lesion,which can predict the stenosis degree of coronary artery in a certain extent.